醒脾消食汤合刺四缝治疗小儿厌食症的临床疗效观察  

Clinical Observation of Xingpi Xiaoshi Decoction Combined with Needling Sifeng Extra Points in the Treatment of Infantile Anorexia

作　　者：闻思齐 傅伟 李维军 WEN Si-Qi;FU Wei;LI Wei-Jun(Bao’an Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518000 Guangdong,China)

机构地区：[1]广州中医药大学附属宝安中医院,广东深圳518000

出　　处：《广州中医药大学学报》2021年第2期273-278,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：深圳市科技计划项目(编号:JCYJ20180302144752020)。

摘　　要：【目的】观察醒脾消食汤联合刺四缝穴治疗小儿厌食症的疗效,评估其对血清瘦素及增食欲素水平的影响。【方法】将60例厌食症患儿随机分为试验组和对照组,每组各30例。对照组患儿给予口服五维赖氨酸颗粒治疗,试验组患儿给予醒脾消食汤联合刺四缝穴治疗,疗程为1个月。观察2组患儿治疗前后中医证候积分、血清瘦素及增食欲素水平的变化情况,评价2组患儿的临床疗效和安全性。【结果】(1)治疗1个月后,试验组的总有效率为96.7%(29/30),对照组为70.0%(21/30),试验组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患儿的中医证候积分均较治疗前明显降低(P<0.05),且试验组的降低作用明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患儿的血清瘦素水平均较治疗前明显降低,增食欲素水平均较治疗前明显升高(P<0.05),且试验组对血清瘦素水平的降低作用和对增食欲素水平的升高作用均明显优于对照组,差异均有统计学意义(P<0.05)。(4)治疗过程中,2组患儿均无过敏等明显的不良反应发生,血常规和肝肾功能也均无明显异常改变。【结论】采取醒脾消食汤联合刺四缝穴治疗小儿厌食症疗效显著,可有效改善患儿的临床症状,调节患儿的血清瘦素与增食欲素水平,其疗效明显优于西药治疗。Objective To observe the clinical effect of Xingpi Xiaoshi Decoction combined with needling Sifeng(EX-UE10)extra points on infantile anorexia,and to evaluate its influence on serum leptin and orexin levels.Methods Sixty children with infantile anorexia were randomly divided into trial group and control Group,with30 cases in each group.The control group was treated with Five Vitamins and Lysine Hydrochloride Granules,and the trial group was treated with Xingpi Xiaoshi Decoction combined with needling Sifeng(EX-UE10)extra points.The treatment course lasted for one month.Before and after treatment,the scores of traditional Chinese medicine(TCM)syndrome and serum levels of leptin and orexin in the two group were observed.At the end of the course of treatment,we evaluated the clinical effect and safety in the two groups.Results(1)After treatment for one month,the total effective rate of the trial group was 96.7%(29/30),and was higher than that of the control group(70.0%,21/30).The intergroup comparison showed that the trial group had stronger efficacy than the control group,the difference being statistically significant(P<0.05).(2)After treatment,the TCM syndrome scores in the two groups were markedly decreased(P<0.05 compared with those before treatment),and the decrease in the trial group was superior to that in the control group,the difference being statistically significant(P<0.05).(3)After treatment,serum leptin level in the two groups was obviously decreased and orexin level was increased in comparison with those before treatment(P<0.05),and the decrease of leptin level and the increase of orexin level in the trial group were superior to that in the control group,the difference being statistically significant(P<0.05).(4)During the trial,no obvious adverse reaction such as allergic reaction occurred in the two groups,or no abnormal changes were found in the blood routine test as well as the hepatic and renal function.Conclusion Xingpi Xiaoshi Decoction combined with needling Sifeng(EX-UE10)extra points exerts cer

关 键 词：醒脾消食汤 刺四缝穴 小儿厌食症 瘦素 增食欲素 

分 类 号：R246.4[医药卫生—针灸推拿学]