广西某美沙酮维持治疗门诊HCV抗体阳性就诊者病毒载量及相关因素分析  

HCV-RNA viral load and its related factors among anti-HCV positive attendants in a methadone maintenance treatment clinic in Guangxi

作　　者：李荣健[1] 潘玲 石珊 韦利葵 蓝光华[1] 庞琳[2] LI Rong-jian;PAN Ling;SHI Shan;WEI Li-kui;LAN Guang-hua;PANG Lin(Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning,Guangxi 530028,China;National Center for AIDS/STD Control and Prevention,China CDC,Beijing 102206,China;Red Cross Hospital of Nanning City,Nanning,Guangxi 530012,China)

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028 [2]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206 [3]南宁市红十字会医院,广西南宁530012

出　　处：《实用预防医学》2021年第1期29-31,共3页Practical Preventive Medicine

基　　金：中美艾滋病防治合作项目(5uzGGH001153)。

摘　　要：目的检测广西某美沙酮维持治疗(methadone maintenance treatment,MMT)门诊丙型肝炎病毒(hepatitis C,HCV)抗体阳性者的HCV病毒载量探讨其相关影响因素。方法对广西南宁市MMT门诊HCV抗体阳性就诊者进行调查,收集一般人口学信息、吸毒及HIV感染情况等,并进行HCV病毒载量、血常规、肝功能等测定。结果共检测257人,其中209人(81.32%)HCV-RNA阳性,48人(18.68%)HIV抗体阳性,139人(54.09%)AST/ALT>1;随着HCV-RNA载量升高,AST和ALT异常比例及HCV/HIV合并感染比例增加(χ^2趋势检验,均P<0.05)。结论MMT门诊中HCV抗体阳性者大多为现症丙型病毒性肝炎(简称丙肝)患者,部分已进展到肝纤维化或肝硬化,且病毒载量与AST、ALT异常及HIV合并感染有关,提示应重视该人群的丙肝防治,并遏制HCV进一步传播。Objective To detect the HCV-RNA viral load among anti-HCV positive attendants in a methadone maintenance treatment(MMT)clinic in Guangxi,and to explore its associated influencing factors.Methods We surveyed anti-HCV positive attendants in a methadone maintenance treatment(MMT)clinic in Guangxi Province.Their information about general demography,drug addiction and HIV infection status was collected,and laboratory tests including HCV-RNA viral load,blood routine and liver function were conducted.Results A total of 257 anti-HCV positive attendants received the above-mentioned laboratory tests.Among them,209(81.32%)were HCV-RNA-positive,48(18.68%)were HIV positive,and 139(54.09%)had an AST/ALT ratio above 1.Along with the growth of HCV-RNA viral load,the rates of abnormal AST value,abnormal ALT value and HCV/HIV co-infection all increased(Chi-square test for trend test,all P<0.05).Conclusions Most of the anti-HCV positive attendants in the MMT clinic are patients with chronic hepatitis C virus infection,and some of them have already developed into liver fibrosis or cirrhosis.In addition,the viral load is correlated with abnormal AST value,abnormal ALT value,and HIV/HCV co-infection.It is suggested that more attention should be paid to HCV prevention and treatment so as to contain further spread of HCV.

关 键 词：美沙酮维持治疗 丙型病毒性肝炎 病毒载量 HIV 肝功能 

分 类 号：R512.91[医药卫生—内科学]