抗着丝点抗体B阳性的临床价值探讨  

Clinical value of anti centromere antibody B positive

作　　者：陈敏[1] 郭维 高亚玲 杨军[1] CHEN Min;GUO Wei;GAO Yaling;YANG Jun(Department of Clinical Laboratory,Affiliated Hospital of Chengdu University,Chengdu,Sichuan 610000,China)

机构地区：[1]成都大学附属医院检验科,四川成都610000

出　　处：《国际检验医学杂志》2021年第1期96-98,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨抗着丝点抗体蛋白B(CENP-B)在自身免疫性疾病诊断中的价值。方法回顾性分析该院检测自身抗体谱的患者资料,选取血清抗CENP-B抗体结果为阳性的患者,收集其相关临床资料。观察抗CENP-B抗体阳性患者其抗核抗体(ANA)荧光核型模式分布情况,根据其结果分为CENP-B(+)ANA(着丝点型)组和CENP-B(+)ANA(非着丝点型)组,检测并比较2组相关实验室指标水平。结果抗CENP-B抗体阳性患者其疾病诊断主要以自身免疫性疾病为主;抗CENP-B抗体阳性患者其ANA荧光核型模式分布主要以着丝点型为主;免疫球蛋白(Ig)G和IgM水平在2组中比较,差异有统计学意义(P<0.05)。结论抗CENP-B抗体可作为自身免疫性疾病的筛选指标,为临床的诊断和治疗提供了一定的参考价值。Objective To analyze the value of anti centromere antibody protein B(CENP-B)in the diagnosis of autoimmune diseases.Methods The data of patients with autoantibody spectrum detected in our hospital were retrospectively analyzed.The patients with positive serum anti CENP-B antibody were selected and their clinical data were collected.The distribution of antinuclear antibody(ANA)fluorescence karyotype pattern in patients with positive anti CENP-B antibody were observed.According to the results,they were divided into CENP-B(+)ANA(centromeric type)group and CENP-B(+)ANA(non centromeric type)group.The levels of relevant laboratory indexes were detected and compared between the two groups.Results The diagnosis of patients with positive anti CENP-B antibody was mainly autoimmune diseases;the distribution of ANA fluorescence karyotype pattern in patients with positive anti CENP-B antibody was mainly centromere type;the levels of immunoglobulin(Ig)G and IgM were significantly differents between the two groups(P<0.05).Conclusion Anti CENP-B antibody can be used as a screening index for autoimmune diseases,which provides a certain reference value for clinical diagnosis and treatment.

关 键 词：抗着丝点抗体蛋白B 抗核抗体 自身免疫性疾病 着丝点型 

分 类 号：R446.6[医药卫生—诊断学]