自体软骨细胞联合Ⅰ型胶原治疗剥脱性膝骨软骨炎  

Treatment of osteochondritisdissecans of knee with autologous chondrocytes combined with typeⅠcollagen scaffold

作　　者：郭道瑞 曲春霞 战怀杰 Guo Daorui;Qu Chunxia;Zhan Huaijie(Qingdao Huangdao District Central Hospital, Qingdao 266555, China;Laixi People's Hospital,Qingdao 2266600, China;The Third People's Hospital of Huangdao District,Qingdao 266409, China)

机构地区：[1]青岛市黄岛区中心医院,266555 [2]莱西市人民医院,青岛266600 [3]黄岛区第三人民医院,青岛266409

出　　处：《中华关节外科杂志（电子版）》2020年第6期773-775,共3页Chinese Journal of Joint Surgery(Electronic Edition)

摘　　要：目的探讨自体软骨细胞联合Ⅰ型胶原蛋白三维支架治疗膝关节剥脱性骨软骨炎的疗效。方法选取近5年来在青岛市黄岛区中心医院采用自体软骨细胞联合Ⅰ型胶原蛋白三维支架治疗膝关节剥脱性骨软骨炎的患者12例,用单因素方差分析评估术前与术后6个月、12个月国际膝关节文献委员会(IKDC)膝关节评估表、Lysholm膝关节功能评分。术后12个月磁共振成像(MRI)评估软骨修复情况。结果12例患者术后6个月、12个月的IKDC评分分别为(83.7±5.6)、(91.7±3.7),Lysholm评分分别为(87.5±5.2)、(93.6±2.1),均较术前IKDC评分(53.9±6.7)(F=158.877)、Lysholm评分(59.1±7.2)(F=104.258)明显改善(均为P<0.05);每2个时间点之间的IKDC评分、Lysholm评分,差异均具有统计学意义(P<0.05)。术后12个月MRI检查显示,所有患者的移植软骨恢复良好,均未出现移植物脱落或局部水肿。术后随访期内,所有患者均未出现膝关节感染。结论自体软骨细胞联合Ⅰ型胶原蛋白三维支架能有效治疗膝关节剥脱性骨软骨炎。Objective To investigate the effect of autologous chondrocytes combined with typeⅠcollagen three-dimensional scaffold in the treatment of knee osteochondritis dissecans.Methods Twelve patients with osteochondritisdissecanswere treated with autologous chondrocytes combined with type I collagen three-dimensional scaffolds in Qingdao Huangdao District Central Hospital in recent five years.The IKDC knee joint score and Lysholm knee joint function score were evaluated before and six months and 12 months after the operation by one-way ANOVA.The cartilage repair was evaluated by magnetic resonance imaging(MRI)12 months after the operation.Results The IKDC and Lysholm scores of 12 patients were(83.7±5.6)and(91.7±3.7)at six months,and(87.5±5.2)and(93.6±2.1)at 12 months after operation,which were significantly improved compared with those before operation(53.9±6.7)for IKDC(F=158.877)and(59.1±7.2)for Lysholm(F=104.258),and the differences were statistically significant(both P<0.05).The differences of IKDC score and Lysholm score between each two time points were statistically significant(all P<0.05).MRI examination at 12 months after operation showed that the grafted cartilage of all cases recovered well,and there was no graft abscission or local edema.During the follow-up period,no knee infection occurred in all patients.Conclusion Autologous chondrocytes combined with typeⅠcollagen three-dimensional scaffold can effectively treat osteochondritisdissecans of knee joint.

关 键 词：软骨细胞 胶原Ⅰ型 骨软骨炎 剥脱性 

分 类 号：R681.3[医药卫生—骨科学]