子痫前期孕妇血清维生素D水平与维生素D受体基因多态性的相关性  

Correlation between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphism in Preeclampsia Pregnant Women

作　　者：李祥雯[1] 李晶[1] 朱启英[1] Li Xiangwen;Li Jing;Zhu Qiying(Department of Obstetrics,The First Affiliated Hospital of Xinjiang Medical University,Xinjiang 830054,China)

机构地区：[1]新疆医科大学第一附属医院产科,乌鲁木齐830054

出　　处：《医学研究杂志》2021年第1期104-108,共5页Journal of Medical Research

基　　金：新疆维吾尔自治区自然科学基金资助项目(面上项目)(2019D01C317)。

摘　　要：目的探讨子痫前期(preeclampsia,PE)孕妇血清维生素D水平与维生素D受体(vitamin D receptor,VDR)基因多态性的相关性,分析VDR与子痫前期的关系。方法选取2018年2月~2019年4月新疆医科大学第一附属医院收治的子痫前期孕妇100例为PE组,另选取同期健康孕妇100例为对照组;比较两组孕妇一般资料及VDR基因位点BsmI、ApaI、ForI、TaqI表达多态性差异;再根据孕妇血清1,25(OH)2D 3是否低于30ng/ml进行亚组分析。结果PE组孕妇血清1,25(OH)2D 3、血钙及白蛋白水平低于对照组,甘油三酯水平高于对照组,差异有统计学意义(P<0.05);在低1,25(OH)2D 3水平孕妇中,PE组VDR基因位点中BsmI GG基因型、G等位基因频率及ForI CC基因型、C等位基因频率高于对照组,差异有统计学意义(P<0.05);在正常1,25(OH)2D 3水平孕妇中,PE组与对照组各VDR基因位点的基因型及等位基因频率情况差异无统计学意义(P>0.05)。结论子痫前期孕妇体内维生素D水平较低,低维生素D水平且BsmI位点GG基因型及ForI位点CC基因型比例较高的孕妇易发生子痫前期。Objective To explore the correlation between serum vitamin D levels and vitamin D receptor(VDR)gene polymorphisms in pregnant women with preeclampsia(PE),and to analyze the relationship between VDR and preeclampsia.Methods A total of 100 cases of preeclampsia pregnant women treated in the First Affiliated Hospital of Xinjiang Medical University from February 2018 to April 2019 were selected as PE group,and 100 healthy pregnant women were selected as control group.The general information of pregnant women and the expression polymorphisms of BsmI,ApaI,ForI,TaqI in the VDR gene loci between the two groups were compared.Subgroup analysis was performed based on whether the serum of pregnant women 1,25(OH)2D 3 was lower than 30ng/ml.Results The serum 1,25(OH)2D 3,serum calcium and albumin levels of the pregnant women in the PE group were lower than those in the control group,and the triglyceride levels were higher than those in the control group,and the differences were statistically significant(P<0.05).Among 1,25(OH)2D 3 low-level pregnant women,the BsmI GG genotype,G allele frequency,ForI CC genotype,and C allele frequency in the VDR locus in the PE group were higher than those in the control group,and the differences were statistically significant.Significance(P<0.05).In normal pregnant women with 1,25(OH)2D 3 levels,there was no significant difference in genotype and allele frequency between VDR loci in the PE group and the control group(P>0.05).Conclusion Preeclampsia pregnant women have low vitamin D levels,low vitamin D levels,and pregnant women with a high proportion of GG genotypes at the BsmI site and CC genotypes at the ForI site are prone to preeclampsia.

关 键 词：子痫前期 维生素D 维生素D受体 基因多态性 相关性 

分 类 号：R714.2[医药卫生—妇产科学]