雄性生殖系统中瘦素表达及功能的研究进展  

Leptin and Male Reproduction

作　　者：金明昊 黄文一 张梦旖 张一苇 刘悦 丁之德 JIN Ming-hao;HUANG Wen-yi;ZHANG Meng-yi;ZHANG Yi-wei;LIU Yue;DING Zhi-de(Department of Clinical Medicine,Grade 2018,8 Years Program,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China;Department of Histology,Embryology,Genetics and Developmental Biology,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院临床医学系,200025 [2]上海交通大学医学院组织胚胎学与遗传发育学系,200025

出　　处：《国际生殖健康／计划生育杂志》2021年第1期38-43,共6页Journal of International Reproductive Health/Family Planning

基　　金：上海交通大学医学院第十四期大学生创新训练计划(1420Y014),上海交通大学基础医学院第十四期RBL项目(2020001)。

摘　　要：男性生育力呈下降趋势,阐明其发生机制有助于男性不育症的精准医疗。瘦素是一种主要由脂肪组织产生的激素,在调节机体能量代谢、参与炎性反应、促进生殖系统发育及维持其正常功能等方面具有重要的作用。瘦素及其受体在哺乳动物下丘脑-垂体-性腺(HPG)轴的内分泌器官、睾丸、生殖道、附属生殖腺以及精子中均有广泛表达,其表达异常与雄性生殖系统发育迟缓或功能障碍相关。阐明瘦素在雄性生殖系统中的表达及作用机制可为临床上治疗男性不育等相关疾病提供重要的理论基础。The downward trend in male fertility has become increasingly obvious in the world.To clarify the etiology and pathogenesis of this trend is very helpful for the precision treatment of male infertility.Leptin,a hormone produced mainly by adipose tissue,plays an important role in regulating energy metabolism,responding to inflammation,promoting the development of reproductive system and maintaining reproductive function.Leptin and its receptor can widely express in mammals′HPG axis,testicular tissue,genital tract,accessory glands and sperm.The abnormal expression of leptin is related to the delayed development or dysfunction of the male reproductive system.To verify the leptin expression in male reproductive system and to elucidate its molecular mechanism may provide critical theoretical evidences for the clinical treatment of reproductive diseases such as male infertility.

关 键 词：瘦素 受体 瘦素 泌尿生殖系统 生育力 精子发生 下丘脑-垂体-性腺轴 

分 类 号：R339.21[医药卫生—人体生理学]