早发性卵巢功能不全患者辅助生殖药物预处理新进展  

New Progress in Drug Pretreatment in Patients with Premature Ovarian Insufficiency

作　　者：帅领 刁瑞英[2] 吴莎 钟梅[1] 汪丽萍 SHUAI Ling;DIAO Rui-ying;WU Sha;ZHONG Mei;WANG Li-ping(Department of Obstetrics and Gynecology,Nanfang Hospital of Southern Medical University,Guangzhou 510515,China;Department of Reproductive Medicine,First Affiliated Hospital of Shenzhen University,Shenzhen 518035,China;Department of Obstetrics and Gynecology,People′s Hospital of Baoan District,Shenzhen 518101,China)

机构地区：[1]南方医科大学南方医院妇产科,广州510515 [2]深圳大学第一附属医院生殖医学科 [3]深圳市宝安区人民医院妇产科

出　　处：《国际生殖健康／计划生育杂志》2021年第1期53-59,共7页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(81571389)。

摘　　要：早发性卵巢功能不全(POI)是一种严重影响生育期女性身心健康的异质性疾病,发病机制不明。对于POI患者,目前尚缺乏有效手段来预防和(或)恢复其正常卵巢储备功能。对有生育需求的POI患者,适时或及时接受辅助生殖治疗可提高其妊娠率和活产率。行辅助生殖治疗前,对POI患者进行个体化生育力评估,采用多种预处理方案,能有效改善卵巢低反应(POR),提高辅助生殖的成功率并改善妊娠结局。对POI患者可采用的有关辅助生殖药物预处理的最新进展进行综述,包括激素类药物、抗氧化应激制剂、免疫调节剂、抗凝剂和代谢调节剂,旨在为个体化精准辅助生殖预处理的选择提供参考和借鉴。事实上,POI患者辅助生殖药物预处理对改善妊娠结局非常必要。Premature ovarian insufficiency(POI) is a heterogeneous disease that seriously affects the physical and mental health of women during childbearing period. However, the pathogenesis of POI is still unknown. For patients with POI, there is no effective means to prevent and/or restore their normal ovarian reserve.For those POI patients with fertility needs, the timely assisted reproductive treatment can improve their pregnancy rate and live birth rate. Individual fertility assessment of POI patients before assisted reproductive therapy, using a variety of pretreatment regimens, can effectively improve the poor ovarian response(POR), increase the success rate of assisted reproduction and improve pregnancy outcome. This article reviewed the progress in the pretreatment with assisted reproductive drugs in POI patients, including hormonal drugs, antioxidant stress agents,immunomodulators, anticoagulants and metabolic regulators, in order to provide reference for the selection of individual treatment protocols. It is true that the pretreatment with assisted reproductive drugs in patients with POI is very important for improving the pregnancy outcome.

关 键 词：原发性卵巢功能不全 生殖技术 辅助 移植预处理 抗氧化剂 免疫调节 

分 类 号：R714.8[医药卫生—妇产科学]