冠心病伴H型高血压患者血清不对称二甲基精氨酸、β2微球蛋白、抵抗素与冠脉病变程度的关系  

Relationship between Serum Asymmetric Dimethylarginine,β2 microglobulin,Resistin and Degree of Coronary Lesion in Patients with Coronary Heart Disease Complicated with H-type Hypertension

作　　者：侯光强[1] 柏勇 周玉龙[1] Hou Guangqiang;Bai Yong;Zhou Yulong(Department of Cardiovascular Medicine,the Fourth People's Hospital of Guangyuan,Guangyuan 628000)

机构地区：[1]广元市第四人民医院心血管内科,广元628000

出　　处：《国际老年医学杂志》2021年第1期24-27,共4页International Journal of Geriatrics

摘　　要：目的探讨冠心病(CHD)合并H型高血压患者血清不对称二甲基精氨酸(ADMA)、β2微球蛋白(β2MG)、抵抗素与冠脉病变程度的关系。方法选取2017年5月~2017年12月广元市第四人民医院心血管内科确诊的CHD合并高血压患者210例,根据患者血清同型半胱氨酸(Hcy)水平分组,Hcy≥10μmol/L为CHD伴H型高血压(CHD-H)组97例,Hcy<10μmol/L为CHD伴非H型高血压(CHD-NH)组113例。对比两组的收缩压(SBP)、舒张压(DBP)、血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、ADMA、β2MG、抵抗素水平,并按照冠脉病变支数将CHD-H组进行分层分析,探讨ADMA、β2MG、抵抗素与CHD-H组患者Gensini评分的关系。结果CHD-H组Hcy、ADMA、β2MG、抵抗素水平显著高于CHD-NH组,差异均具有统计学意义(P<0.001);CHD-H组Gensini评分与CHD-NH组比较,差异不具有统计学意义(P>0.05);单支、双支及三支冠脉病变的CHD-H组ADMA、β2MG、抵抗素水平逐渐升高,组间两两比较差异均具有统计学意义(P<0.001);CHD-H组ADMA、β2MG、抵抗素水平与冠脉Gensini评分均呈显著的正相关关系(P<0.001)。结论CHD伴H型高血压患者血清ADMA、β2MG、抵抗素水平显著升高,并且与患者冠脉病变严重程度有密切的关系。Objective To investigate the relationship between serum asymmetric dimethylarginine(ADMA),β2 microglobulin(β2MG),resistin and coronary lesion in patients with coronary heart disease(CHD)complicated with H-type hypertension.Methods 210 patients with CHD and hypertension in the Fourth People's Hospital of Guangyuan were selected from May 2017 to December 2017.The patients were divided into two groups according to the level of serum homocysteine(Hcy).97 CHD patients with H-type hypertension(Hcy level≥10μmol/L)were assigned into CHD-H group,and 113 CHD patients with non-H-type hypertension(Hcy level<10μmol/L)were assigned into CHD-NH group.The levels of systolic blood pressure(SBP),diastolic blood pressure(DBP),triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),ADMA,β2MG,and resistin were compared between the two groups.CHD-H group was further analyzed according to the number of stenotic coronary artery.The relationship between ADMA,β2MG,resistin and Gensini score in CHD patients with H-type hypertension was investigated.Results The levels of Hcy,ADMA,β2MG,and resistin in CHD-H group were significantly higher than those in CHD-NH group(P<0.001).There was no significant difference in Gensini score between CHD-H group and CHD-NH group(P>0.05).The levels of ADMA,β2MG and resistin gradually increased with single vessel lesion,double vessel lesion and triple vessel lesion in the patients of CHD-H group,and there was significant difference between these patients(P<0.001).The levels of ADMA,β2MG,and resistin were significantly positively correlated with the coronary Gensini score in CHD-H group(P<0.001).Conclusion Serum ADMA,β2MG,and resistin were significantly elevated in CHD patients with H-type hypertension,and were closely related to the severity of coronary artery disease.

关 键 词：冠心病 H型高血压 不对称二甲基精氨酸 Β2微球蛋白 抵抗素 

分 类 号：R541.4[医药卫生—心血管疾病] R544.1[医药卫生—内科学]