Nephrotic syndrome in syngeneic hematopoietic stem cell transplantation recipients: A case report  

作　　者：Ming-Chuan Bai Jing-Jing Wu Kou-Rong Miao Jing-Feng Zhu Hui-Juan Mao 

机构地区：[1]Department of Nephrology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China [2]Department of Hematology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2021年第3期614-622,共9页世界临床病例杂志

基　　金：the National Natural Science Foundation of China,No.8197039;and 2017 Jiangsu Commission of Health Research Project,No.H2017023.

摘　　要：BACKGROUND Hematopoietic stem cell transplantation(HSCT)is widely used in the treatment of hematological diseases.However,complications after transplantation,such as acute and chronic graft-vs-host disease(GVHD),still seriously affect the quality of life and even threaten the lives of patients.There is evidence that glomerular diseases can manifest as GVHD.However,GVHD should not occur as a result of syngeneic HSCT.CASE SUMMARY A 20-year-old male diagnosed with T lymphoblastic lymphoma(stage IIIA,aaIPI 1)in September 2013 was treated with six cycles of hyper-CVAD and achieved complete remission.He underwent syngeneic HSCT in June 2014,and had no kidney disease history before the transplant.However,nephrotic syndrome occurred 24 mo later in the patient after syngeneic HSCT.Renal biopsy was performed,which led to a diagnosis of atypical membranous nephropathy.After treatment with glucocorticoids combined with cyclophosphamide and cyclosporine,the nephrotic syndrome was completely relieved.CONCLUSION We report a case of delayed nephrotic syndrome after syngeneic HSCT.Antibodymediated autoimmune glomerular disease may be the underlying mechanism.After treatment with immunosuppressive agents,the nephrotic syndrome was completely relieved but further long-term follow-up is still needed.

关 键 词：Syngeneic hematopoietic stem cell transplantation Nephrotic syndrome Graft vs host disease CYCLOSPORINE Autoimmune glomerular disease Case report 

分 类 号：R457.7[医药卫生—治疗学] R692[医药卫生—临床医学]