Effect of remote ischemic preconditioning among donors and recipients following pediatric liver transplantation:A randomized clinical trial  

作　　者：Bo Qi Xiao-Qiang Wang Shu-Ting Pan Pei-Ying Li Ling-Ke Chen Qiang Xia Li-Qun Yang Wei-Feng Yu 

机构地区：[1]Department of Anesthesiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [2]Clinical Center for Investigation,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [3]Department of Transplantation and Hepatic Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200120,China

出　　处：《World Journal of Gastroenterology》2021年第4期345-357,共13页世界胃肠病学杂志（英文版）

基　　金：Supported by Renji Hospital Clinical Innovation Foundation,No.PYIII-17-002;Outstanding Academic Leaders’Program of Health and Family Planning Commission of Shanghai,No.2017BR042;Investigative Doctor Program(2017)of Shanghai Jiao Tong University School of Medicine;Joint Project of Health and Family Planning Commission of Pudong District,No.PW2015D-3.

摘　　要：BACKGROUND Studies suggested that remote ischemic preconditioning(RIPC)may effectively lessen the harmful effects of ischemia reperfusion injury during organ transplantation surgery.AIM To investigate the protective effects of RIPC on living liver donors and recipients following pediatric liver transplantation.METHODS From January 2016 to January 2019 at Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine,208 donors were recruited and randomly assigned to four groups:S-RIPC group(no intervention;n=55),D-RIPC group(donors received RIPC;n=51),R-RIPC group(recipients received RIPC,n=51)and DR-RIPC group(both donors and recipients received RIPC;n=51).We primarily evaluated postoperative liver function among donors and recipients and incidences of early allograft dysfunction,primary nonfunction and postoperative complications among recipients.RESULTS RIPC did not significantly improve alanine transaminase and aspartate aminotransferase levels among donors and recipients or decrease the incidences of early allograft dysfunction,primary nonfunction,and postoperative complications among recipients.Limited protective effects were observed,including a lower creatinine level in the D-RIPC group than in the S-RIPC group on postoperative day 0(P<0.05).However,no significant improvements were found in donors who received RIPC.Furthermore,RIPC had no effects on the overall survival of recipients.CONCLUSION The protective effects of RIPC were limited for recipients who received living liver transplantation,and no significant improvement of the prognosis was observed in recipients.

关 键 词：Pediatric liver transplantation Remote ischemic preconditioning Postoperative complications Ischemia reperfusion injury Primary nonfunction HEPATOLOGY 

分 类 号：R726.5[医药卫生—儿科]