肾康栓对慢性肾脏病患者肠源性尿毒症毒素硫酸对甲酚和硫酸吲哚酚的影响  

Effect of Shenkang Suppository on Enterogenous Uremic Toxin,P-cresol Sulfate and Indole Sulfate in Patients with Chronic Kidney Disease

作　　者：李鹏 钟晓菁[1,2] 张丽红 余莹[1,2] 牛建英 覃乔静[1,2] LI Peng;ZHONG Xiaojing;ZHANG Lihong(Department of Nephrology,Shanghai Fifth People’s Hospital,Fudan University,Shanghai 200240)

机构地区：[1]复旦大学附属上海市第五人民医院肾内科,上海200240 [2]复旦大学社区健康研究中心(筹),上海200240

出　　处：《中国中西医结合肾病杂志》2020年第11期959-961,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：上海市闵行区科委自然科学研究项目(No.2019MHZ124);上海市闵行区重点专科建设项目(No.2017MWTZ04)。

摘　　要：目的:探讨肾康栓对慢性肾脏病(chronic kidney disease,CKD)患者血清肠源性尿毒症毒素硫酸吲哚酚(indoxylsulfate,IS)、硫酸对甲酚(p-cresylsulfate,PCS)的影响。方法:将120例CKD3~4期患者随机分成治疗组和对照组各60例,治疗组在常规治疗基础上加用肾康栓;8周后比较两组的临床疗效和生化指标变化,并用高效液相色谱-电喷雾电离-串联质谱(HPLC-ESI-MS/MS)法测定两组血清IS及PCS变化。结果:治疗组临床总有效率为75.0%,对照组总有效率为51.7%,两组差异具有统计学意义(P<0.05)。治疗后肾康栓组血清IS、PCS均显著降低,对照组仅PCS轻度降低(P<0.05)。结论:CKD患者采用肾康栓治疗,能有效地改善症状,减轻或延缓肾功能损害,是安全有效的辅助治疗方法。Objective:To investigate the effect of Shenkang suppository on intestinal uremic toxin indoxylsulfate(IS)and p-cresolsulfate(PCS)in patients with chronic kidney disease stage 3-4.Methods:120 cases of CKD stage 3-4 patients were randomly divided into 60 cases in the treatment group and 60 cases in the control group.Both groups were treated with conventional treatment,and the treatment group was treated with Shenkang suppository and anal treatment.After 8 weeks,the clinical efficacy and biochemical indexes of the two groups were compared,and the changes of serum IS and PCS in the two groups were determined by HPLC-ESI-MS/MS.Results:The total clinical effective rate was 75.0%in the treatment group and 51.7%in the control group.The difference between the two groups was statistically significant(P<0.05).After treatment,the serum IS and PCS in Shenkang suppository group were significantly reduced,while the control group only had a slight decrease in PCS(P<0.05).Conclusion:Shenkang suppository treatment can effectively improve the clinical symptoms of patients with chronic kidney disease,reduce or delay the impairment of renal function,and is a safe and effective adjuvant treatment method.

关 键 词：慢性肾脏病 肾康栓 硫酸吲哚酚 硫酸对甲酚 

分 类 号：R692.5[医药卫生—泌尿科学]