Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp.NF2410  

作　　者：LI Wei WEI Jing CHEN Dao-Ying WANG Mei-Jing SUN Yang JIAO Fang-Wen JIAO Rui-Hua TAN Ren-Xiang GE Hui-Ming 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,Institute of Functional Biomolecules,School of Life Sciences,Nanjing University,Nanjing 210023,China [2]State Key Laboratory of Pharmaceutical Biotechnology,Department of Biotechnology and Pharmaceutical Sciences,School of Life Science,Nanjing University,Nanjing 210023,China [3]State Key Laboratory Cultivation Base for TCM Quality and Efficacy,Nanjing University of Chinese Medicine,Nanjing 210023,China

出　　处：《Chinese Journal of Natural Medicines》2020年第12期957-960,共4页中国天然药物（英文版）

基　　金：supported by the Ministry of Science and Technology(Nos.2018YFC1706200 and 2018YFA.902000);the National Natural Science Foundation of China(Nos.81925033,21861142005,81773591,21761142001,81673333,21661140001,and 91853109)。

摘　　要：Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives,arthrianhydride A(1)and B(2),along with three known compounds 3-5,were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp.NF2410.The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data.Furthermore,compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.

关 键 词：Grasshopper-associated fungi Secondary metabolites Structure elucidation SHP2 Inhibitory activity 

分 类 号：R284[医药卫生—中药学]