3型心肾综合征的发病机制  

Pathogenesis of cardiorenal syndrome type 3

作　　者：王梦竹(综述) 乔晞(审校)[2] WANG Mengzhu;QIAO Xi(Department of Nephrology,the second hospital of Shanxi Medical University;Shanxi Institute of Nephrology,Institute of Nephrology,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学 [2]山西医科大学第二医院肾内科,山西省肾脏病研究所,山西医科大学肾脏病研究所,太原030001

出　　处：《肾脏病与透析肾移植杂志》2020年第6期562-566,576,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金面上项目(81970643);山西省回国留学人员科研资助项目(2020-186);山西省留学回国人员科技活动择优资助项目(2017-29)。

摘　　要：急性肾损伤(AKI)是一种常见而严重的疾病。近期发现,AKI通过复杂的机制影响其他器官系统,导致远隔器官损伤,临床上最常见的损伤发生在肺、心脏、肝和肠。AKI引起的心血管疾病(CVD)包括心功能不全、冠脉综合征、心律失常等,其中,AKI引起的急性心功能不全又被称为3型心肾综合征或急性肾心综合征。研究表明,AKI后CVD可能与以下三个方面相关:(1)AKI引起内环境紊乱;(2)AKI介导全身炎性反应;(3)肾脏替代疗法的影响。本文将阐述AKI患者的心血管受累情况及可能机制。Acute kidney injury(AKI)is a common and serious disease.Recently,it has been found that AKI affects other organs and systems through complex mechanisms,leading to distant organ damage.Clinically,the most common damage occurs in the lung,heart,liver and intestine.Cardiovascular disease(CVD)caused by AKI includes cardiac insufficiency,coronary syndrome,arrhythmia and so on.Among them,acute cardiac insufficiency after AKI is also known as cardiorenal syndrome type 3 or acute renal heart syndrome.Studies have shown that cardiovascular disease after AKI may be related to the following three aspects:(1)internal environment disorder caused by AKI;(2)AKI mediated systemic inflammatory response;(3)adverse effects caused by renal replacement therapy(RRT).This paper will describe cardiovascular disease and possible mechanisms in AKI patients.

关 键 词：急性肾损伤 远隔器官 3型心肾综合征 

分 类 号：R69[医药卫生—泌尿科学]