继发性高草酸尿症的诊治进展  

Diagnosis and treatment of secondary hyperoxaluria

作　　者：于健鹏 谌卫(综述) 郭志勇(审校) YU Jianpeng;CHEN Wei;GUO Zhiyong(Department of Nephrology,Shanghai Changhai Hosptial,Shanghai 200433,China)

机构地区：[1]上海市长海医院肾内科,上海200433

出　　处：《肾脏病与透析肾移植杂志》2020年第6期567-571,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：继发性高草酸尿症是以尿草酸排泄过多及草酸钙晶体沉积为特征的代谢性疾病,其发病因素包括草酸及其前体物质的摄入增加、肠道对草酸盐的吸收增加、肠道菌群失调等。目前对于该病的诊断主要包括尿草酸及血浆草酸盐水平、影像学和肾脏活检,治疗手段包括控制病因、保守治疗、透析及器官移植,一些新的治疗方法需要进一步探索。Secondary hyperoxaluria is a metabolic disease characterized by excessive urinary oxalate excretion and calcium oxalate crystal deposition,whose pathogenic factors include excessive intake of oxalate foods and oxalate precursors,increased intestinal absorption of oxalate,and the alteration of intestinal flora.The current diagnostic methods mainly include urine and plasma oxalic acid levels,imaging examination,and renal biopsy.Treatment options include etiological therapy,conservative measures,dialysis and organ transplantation.In addition,there are other potential treatments that need to be explored.

关 键 词：继发性高草酸尿症 草酸钙 尿草酸 血浆草酸盐 肾活检 

分 类 号：R692[医药卫生—泌尿科学]