百令胶囊联合呼吸康复训练治疗慢性阻塞性肺疾病稳定期临床研究  

Clinical Study on Bailing Capsules Combined with Respiration Rehabilitation Training for Chronic Obstructive Pulmonary Disease at Stable Stage

作　　者：余嗣崇[1] 许新举[1] 乔冬梅[1] 王荣荣 YU Sichong;XU Xinju;QIAO Dongmei;WANG Rongrong

机构地区：[1]焦作市第二人民医院,河南焦作454000 [2]河南理工大学医学院,河南焦作454000

出　　处：《新中医》2020年第24期66-69,共4页New Chinese Medicine

摘　　要：目的:观察百令胶囊联合呼吸康复训练治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法:选择COPD稳定期患者120例,按随机数字表法分为对照组和研究组各60例。对照组给予呼吸康复训练,研究组在对照组基础上应用百令胶囊治疗,治疗3个月。治疗后,评估2组肺功能、痰液中基质金属蛋白酶-9(MMP-9)及相关炎性因子、血液T淋巴细胞亚群水平变化。结果:治疗后,2组一秒钟用力呼气量(FEV1)、一秒钟用力呼气量占用力肺活量的百分比(FEV1/FVC)、BODE指数及慢性阻塞性肺病评估测试评分量表(CAT)评分均优于治疗前,差异均有统计学意义(P<0.05);研究组FEV1、FEV1/FVC高于对照组,BODE指数及CAT评分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组痰液中MMP-9、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)均低于治疗前(P<0.05),且研究组痰液中MMP-9、IL-6及TNF-α均低于对照组(P<0.05)。治疗后,2组T淋巴细胞亚群CD3^+、CD4^+、CD4^+/CD8^+均高于治疗前,CD8^+低于治疗前,差异均有统计学意义(P<0.05)。治疗后,研究组T淋巴细胞亚群CD3^+、CD4^+、CD4^+/CD8^+均高于对照组,CD8^+低于对照组,差异均有统计学意义(P<0.05)。结论:在呼吸康复训练基础上,应用百令胶囊辅助治疗COPD稳定期患者,可以显著改善患者肺功能、炎性因子及免疫功能。Objective:To observe the clinical effect of Bailing capsules combined with respiration rehabilitation training for chronic obstructive pulmonary disease(COPD) at stable stage. Methods:A total of 120 cases of COPD patients at stable stage were selected and divided into the control group and the study group according to the random number table method, 60 cases in each group. The control group was given respiration rehabilitation training,and the study group was additionally given Bailing capsules based on the treatment of the control group. Both groups were treated for three months. After treatment,the changes in the lung function was evaluated in the two groups;the levels of matrix metalloproteinase-9(MMP-9) and its related inflammatory factors in sputum,and T lymphocyte subsets in blood were evaluated in the two groups. Results:After treatment,the forced expiratory volume in one second(FEV1),the ratio of FEV1 to forced vital capacity(FEV1/FVC),and the scores of BODE index and COPD Assessment Test(CAT) Scale in the two groups were better than those before treatment,differences being significant(P<0.05). After treatment,FEV1 and FEV1/FVC in the study group were higher than those in the control group, and the scores of BODE index and CAT were lower than those in the control group, differences being significant(P<0.05). After treatment,the levels of MMP-9,interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α) in sputum in the two groups were lower than those before treatment(P<0.05);the three levels above in the study group were lower than those in the control group(P<0.05). After treatment,the levels of CD3^+ ,CD4^+ ,and CD4^+ /CD8^+in T lymphocyte subsets in the two groups were higher than those before treatment, and the CD8^+ level was lower than that before treatment,differences being significant(P<0.05). After treatment,the levels of CD3^+ ,CD4^+ ,and CD4^+ /CD8^+ in T lymphocyte subsets in the study group were higher than those in the control group,and the CD8^+ level was lower than that in the control group,

关 键 词：慢性阻塞性肺疾病 呼吸康复训练 百令胶囊 肺功能 炎性因子 免疫功能 

分 类 号：R563.9[医药卫生—呼吸系统]