从脾肾论治青春期前特发性矮身材伴骨龄落后临床研究  

Clinical Study on Treatment for Idiopathic Short Stature Complicated with Retardation of Bone Age in Prepuberty from the Spleen and Kidney

作　　者：潘丹萍 韩雪[1] 葛国岚 PAN Danping;HAN Xue;GE Guolan

机构地区：[1]郑州大学附属儿童医院,河南郑州450000

出　　处：《新中医》2020年第24期91-93,共3页New Chinese Medicine

基　　金：河南省科技厅科技攻关课题(182102310395)。

摘　　要：目的:观察从脾肾论治青春期前特发性矮身材(ISS)伴骨龄落后的临床疗效。方法:选取64例青春期前ISS伴骨龄落后患儿,按随机数字表法分为治疗组和对照组,每组32例。对照组给予赖氨肌醇维B12口服溶液治疗,并进行饮食指导、健康教育及生活干预,治疗组在对照组基础上给予健脾温肾中药治疗,2组均治疗12个月。观察2组治疗前后身高、体质量、骨龄、血清胰岛素样生长因子-1 (IGF-1)水平的变化,比较2组治疗12个月身高及骨龄增长量。结果:治疗6个月、12个月,2组身高及体质量均较治疗前增长(P<0.05)。治疗6个月,2组身高及体质量比较,差异均无统计学意义(P>0.05)。治疗12个月,治疗组身高及体质量均比对照组增长更明显(P<0.05)。治疗12个月,2组骨龄及IGF-1水平均较治疗前升高(P<0.05);2组骨龄及骨龄增长量比较,差异均无统计学意义(P>0.05);治疗组血清IGF-1水平高于对照组(P<0.05);治疗组身高增长量大于对照组(P<0.05)。结论:从脾肾论治青春期前ISS伴骨龄落后,可促进患儿体内IGF-1合成,加速其身高、体质量增长。Objective: To observe the clinical effect of the treatment for Idiopathic Short Stature(ISS) complicated with retardation of bone age in prepuberty from the spleen and kidney. Methods: A total of 64 cases of ISS children with retardation of bone age in prepuberty were divided into the treatment group and the control group according to the random number table method,32 cases in each group. The control group was treated with lysine inosite vitamin B12 oral solution and given diet guidance,health education and life intervention;the treatment group was additionally treated with Chinese herbal medicine for fortifying the spleen and warming the kidney based on the treatment of the control group. Both groups were treated for 12 months. Before and after treatment,the changes in height,body mass,bone age and Insulin-like Growth Factor-1(IGF-1) levels in the two groups were observed. After twelve-month treatment,the increment of height and bone age in the two groups were compared. Results: After six-month and twelve-month treatment,the height and bone age in the two groups were increased when compared with those before treatment(P<0.05). After six-month treatment,there was no significant difference being found in the comparison of the height and body mass between the two groups(P>0.05). After twelve-month treatment,the increase of height and body mass in the treatment group was more significant than that in the control group(P<0.05). After twelve-month treatment, the bone age and IGF-1 levels in the two groups were increased when compared with those before treatment(P<0.05);there was no significant difference being found in the comparison of the bone age and the increment of bone age between the two groups(P>0.05);the IGF-1 level in serum in the treatment group was higher than that in the control group(P<0.05);the increment of height in the treatment group was more than that in the control group(P<0.05). Conclusion: The treatment for ISS complicated with retardation of bone age in prepuberty from the spleen and kidney can

关 键 词：特发性矮身材 骨龄落后 青春期前 从脾肾论治 身高 体质量 胰岛素样生长因子-1 

分 类 号：R725.8[医药卫生—儿科]