Real-time monitoring and fault detection of pulsed-spray fluid-bed granulation using near-infrared spectroscopy and multivariate process trajectories  

作　　者：Jie Zhao Wenlong Li Haibin Qu Geng Tian Yanding Wei 

机构地区：[1]Pharmaceutical Informatics Institute,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province,College of Mechanical Engineering,Zhejiang University,Hangzhou 310027,China

出　　处：《Particuology》2020年第6期112-123,共12页颗粒学报（英文版）

基　　金：the National Science and Technology Major Project(grant number 2018ZX09201011-002).

摘　　要：Pulsed spray is a useful tool forgranule size control in fluid bed granulation.To improve the quality control of pulsed-spray fluid bed granulation,a combination of in-line near-infrared(NIR)spectroscopy and p「incipal component analysis was used to develop multivariate statistical process control(MSPC)charts.Different types of MSPC charts were developed,including principal component score charts,Hotelling's T2 control charts,and distance to model X control charts,to monitor the batch evolution throughout the granulation process.Correlation optimized warping was used as an alignment method to deal with the time variation in batches caused by the granulation mechanism in MSPC modeling.The control charts developed in this study were validated on normal batches and tested on four batches that deviated from normal processing conditions to achieve real-time fault analysis.The results indicated that the NIR spectroscopy-based MSPC model included the variability in the sample set constituting the model and could withstand external variability.This research demonstrated the application of synchronized NIR spectra in conjunction w让h multivariate batch modeling as an attractive tool for process monitoring and a fault diagnosis method for effective process control in pulsed-spray fluid bed granulation.

关 键 词：Pulsed-spray fluid bed granulation Multivariate statistical process control Multiway principal component analysis Near-infrared spectroscopy Correlation optimized warping 

分 类 号：O657.33[理学—分析化学]