Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex  

作　　者：Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff 

机构地区：[1]Department of Neurology of Affiliated Zhongda Hospital,Institute of Neuropsychiatry and Medical School of Southeast University,Nanjing,210009,China [2]Department of Psychology of Xinxiang Medical University,Xinxiang,453003,China [3]Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,453002,China [4]Deaprtment of Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,211166,China [5]Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai,200030,China [6]Mental Health Center and 7th Hospital,Zhejiang University School of Medicine,Hangzhou,310013,China [7]Royal Ottawa Mental Health Centre,University of Ottawa Institute of Mental Health Research,Ottawa,ON,K1Z 7K4,Canada

出　　处：《Science China(Life Sciences)》2021年第1期96-106,共11页中国科学（生命科学英文版）

基　　金：supported by grants from the National Key Research and Development Program of China(2016YFC1306700 to ZJZ,2016YFC1306704 to HXZ);the National Natural Science Key Foundation of China(81830040 to ZJZ);Science and Technology Program of Guangdong(2018B030334001 to ZJZ);Program of Excellent Talents in Medical Science of Jiangsu Province(JCRCA2016006 to ZJZ);the Program for Innovative Research Team in Science and Technology in University of Henan Province(18IRTSTHN025 to HXZ)。

摘　　要：To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement.

关 键 词：major depressive disorder visual cortex functional magnetic resonance imaging repetitive transcranial magnetic stimulation neuronavigated individualized treatment 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]