一种简单、高效的二苄胺类化合物合成新途径  

A Simple and Highly Efficient Synthesis Method of Dibenzylamine Derivatives

作　　者：徐振华 蒋文佳 王硕文[1] 刘婷 曾政凯 唐石[1] JIANG Wenjia;XU Zhenhua;WANG Shuowen;LIU Ting;ZENG Zhengkai;TANG Shi(College of Chemistry and Chemical Engineering,Jishou Univcrsity,Jishou 416000,China)

机构地区：[1]吉首大学化学化工学院,湖南吉首416000

出　　处：《化工技术与开发》2020年第12期1-4,共4页Technology & Development of Chemical Industry

基　　金：国家自然基金资助项目(21662013);湖南省自然基金(2018jj1020);大学生创新性实验项目(2018ZXCX15,Jdy19018)。

摘　　要：本文建立了一种以芳香苄胺与芳香醛类化合物为原料,通过还原胺醛缩合制备二苄胺类衍生物的方法。该方法操作简单,反应条件较为温和,具有良好的官能团容忍性,底物适应范围广,产率达80%以上。采用熔点和核磁共振氢谱对目标产物进行了表征。此合成方法为官能团化二苄胺类化合物的合成提供了一种高效、便利的新途径,同时也丰富了二苄胺类化合物库。A method for preparation of dibenzylamine derivatives by reducing amine-aldehyde condensation was developed applied aromatic benzylamine and aromatic aldehyde compounds as raw materials. The method was simple operation, mild reaction conditions, good functional group tolerance, wide substrate adaptation range, and the yield was more than 80%. The target product was characterized by melting point and 1 H-NMR. This synthetic method provided a convenient way for the synthesis of functionalized dibenzylamine compounds, and also enriched the dibenzylamine compound library.

关 键 词：芳香苄胺 芳基醛 还原胺醛缩合 二苄胺 取代反应 

分 类 号：O623.731[理学—有机化学]