99Tc^m-MIBI乳腺亲肿瘤显像对乳腺癌的诊断价值分析  

Analysis on the diagnostic value of 99Tcm-MIBI breast tumoraffin imaging on breast cancer

作　　者：江生[1] 黄志顺 肖国有[2] JIANG Sheng;HUANG Zhi-shun;XIAO Guo-you(Department of Nuclear Medicine,The First People's Hospital of Qinzhou 535000,China)

机构地区：[1]钦州市第一人民医院核医学科,广西钦州535000 [2]广西医科大学附属肿瘤医院核医学科,广西南宁535000

出　　处：《中国医学装备》2021年第1期63-67,共5页China Medical Equipment

基　　金：广西壮族自治区卫健委自筹经费科研课题(Z2014494)“乳腺肿块99Tc^m-MIBI亲肿瘤显像的临床研究”。

摘　　要：目的:研究锝99-甲氧基异丁基异腈(99Tc^m-MIBI)乳腺亲肿瘤显像在乳腺癌诊断中的价值。方法:选取80例乳腺肿瘤患者病例资料,其中乳腺癌56例、良性病灶24例。采用单光子发射型电子计算机断层扫描(SPECT/CT)机同机融合功能,将核素断层图像与CT断层扫描图像进行融合分析,对比乳腺癌与良性病灶的显像靶与非显像靶摄取比值(T/N);对比乳腺亲肿瘤显像与超声诊断的检出率。结果:乳腺癌病侧、对侧的T/N(1 h)值均高于良性病灶,乳腺癌患者病侧T/N(1 h)值与良性病灶比较,差异有统计学意义(t=3.650,P<0.05)。99Tc^m-MIBI乳腺亲肿瘤显像诊断的灵敏度、特异度、阳性预测值、阴性预测值及符合率分别为92.9%、87.5%、94.5%、84.0%和91.3%,与超声诊断比较差异无统计学意义。4例乳腺癌漏诊者均为T/N值较低的患者。结论:99Tc^m-MIBI乳腺亲肿瘤显像对乳腺癌具有较高的检出率高,T/N值偏低可能是导致漏诊的主要原因。Objective:To analyze the diagnostic value of technetium 99-methoxyisobutylisonitrile(99Tcm-MIBI)breast tumoraffin imaging on breast cancer.Methods:The data of cases of 80 patients with breast cancer were selected,and 56 cases were breast cancer and 24 cases were benign lesion among of them.The fusion function of same machine of single photon emission computed tomography/computed tomography(SPECT/CT)was adopted,and the nuclide crosssectional images and CT cross-sectional scan images were fused and analyzed.And the uptake ratios(T/N)of target and non-target between breast cancer and benign lesion were compared,and then the detection rates of breast tumoraffin imaging and ultrasound diagnosis were further compared.Results:The T/N value(1h)of the side with disease and the contralateral T/N value of patients with breast cancer were higher than those of patients with benign lesion,and the difference of T/N value(1h)between patients with breast cancer and patients with benign lesion was significant(t=3.650,P<0.05).The sensitivity,specificity,positive predictive value,negative predictive value and coincidence rate of 99Tcm-MIBI breast tumoraffin imaging were 92.9%,87.5%,94.5%,84.0%and 91.3%,respectively,which were no significant difference with those of ultrasound diagnosis.4 cases with breast cancer who were missed diagnosis were patients with lower T/N value.Conclusion:99Tcm-MIBI breast tumoraffin imaging has a favorable detection rate for breast cancer,and the lower T/N ratio may be the main reason for missed diagnosis.

关 键 词：乳腺癌 锝99-甲氧基异丁基异腈(99Tc^m-MIBI) 乳腺亲肿瘤显像 

分 类 号：R817.4[医药卫生—影像医学与核医学]