不同剂量地佐辛术后镇痛对老年患者肝功能的影响  

Effect of postoperative analgesia with different doses of dezocine on liver function in elderly patients

作　　者：李锐[1] 陈红霞 蔡爱球[1] 邓涛 LI Rui;CHEN Hongxia;CAI Aiqiu;DENG Tao(Department of Anesthesiology,the Central People's Hospital of Ji'an City in Jiangxi Province,Ji'an 343000,China)

机构地区：[1]江西省吉安市中心人民医院麻醉科,江西吉安343000

出　　处：《中国现代医生》2020年第34期112-115,共4页China Modern Doctor

基　　金：江西省吉安市科技计划{吉市科计字[2020]20号(5-13)}。

摘　　要：目的探讨地佐辛术后镇痛对高龄患者围术期肝功能的影响。方法选择2018年1月~2020年6月吉安市中心人民医院麻醉科收治的ASA分级Ⅱ~Ⅲ级高龄患者80例,按照随机数字表法,分为A组、B组、C组、D组,每组各20例。分别给予0.4 mg/kg、0.5 mg/kg、0.6 mg/kg、0.7 mg/kg地佐辛进行术后镇痛,评估术后1、2、6、12、24、48 h患者的疼痛程度[视觉模拟评分法(VAS)]、术后镇静效果(Ramsay评分法)及肝功能指标(ALT、AST)水平,评价不同剂量的地佐辛术后镇痛对高龄患者围术期肝功能的影响。结果C组术后患者不同时间段VAS疼痛评分低于A组、B组、D组,差异有统计学意义(P<0.05);四组患者术后1、2、6 h Ramsay镇静评分比较,差异有统计学意义(P<0.05);但术后12、24、48 h Ramay镇痛评分比较,差异无统计学意义(P>0.05)。C组肝功能指标ALT、AST优于A组、B组、D组,差异有统计学意义(P<0.05)。结论高龄患者术后镇痛应用0.6 mg/kg地佐辛对围术期肝功能的影响最小。Objective To investigate the effect of postoperative analgesia with dezocine on liver function in elderly patients during perioperative period.Methods A total of 80 elderly patients with ASA gradeⅡtoⅢadmitted to the Department of Anesthesiology in the Central People's Hospital of Ji'an City from January 2018 to June 2020 were selected.According to the random number table method,they were divided into group A,group B,group C and group D,with 20 cases in each group.And they were treated with 0.4 mg/kg,0.5 mg/kg,0.6 mg/kg,0.7 mg/kg dezocine respectively for postoperative analgesia.The degree of pain at 1,2,6,12,24,48 h after surgery(visual simulation scoring method),postoperative sedation effect(Ramsay scoring method)and liver function index(ALT,AST)levels were evaluated.And the effect of different doses of dezocine postoperative analgesia on perioperative liver function in elderly patients was evaluated.Results The VAS pain score in the group C was lower than that of the group A,group B and group D at different time after operation,the differences were statistical significance(P<0.05).The four groups had different Ramsay sedation scores at 1,2 and 6 h after surgery,the differences were statistical significance(P<0.05).However,there was no significant difference in Ramay analgesia scores at 12,24 and 48 h after surgery(P>0.05).The liver function indexes ALT and AST of the group C were better than group A,B and D,the differences were statistical significance(P<0.05).Conclusion Postoperative analgesia in elderly patients with 0.6 mg/kg dezocine has the least effect on liver function during the perioperative period.

关 键 词：高龄患者 地佐辛 术后镇痛 肝功能 

分 类 号：R971[医药卫生—药品]