健康人群同型半胱氨酸与血脂的水平关系  

Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People

作　　者：邓苙[1] 方红丽 曹光琼 高慧芳 DENG Li;FANG Hong-li;CAO Guang-qiong;GAO Hui-fang(Dept.of Health Management Center,The First Affiliated Hospital of Kumming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院健康管理中心,云南昆明650032

出　　处：《昆明医科大学学报》2021年第1期157-160,共4页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-220)]。

摘　　要：目的采用横断面探讨健康人群血清同型半胱氨酸(Hcy)水平与血脂水平的关系,为Hcy与血脂关系的机制研究提供依据。方法随机选取在2019年1月至2019年11月到云南省某三甲医院健康管理中心进行健康体检的体检者234名作为研究对象,所纳入研究对象均进行血清同型半胱氨酸(Hcy)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)的测量,并采集研究对象一般情况、烟酒史及慢性病史。用统计分析软件SPSS 17.0分析Hcy水平差异及其与血脂等的相关性。结果 (1)男性Hcy水平Md(QR)为12.36(9.90)μmol/L,女性Hcy水平Md(QR)为7.73(6.40)μmol/L,性别间差异具有统计学意义(P <0.001);(2)吸烟史(KW=15.335,P <0.001)、饮酒史(KW=18.937,P <0.001)、LDL-C(r=0.304,P=0.002)、TC(r=0.294,P=0.003)均与Hcy水平相关。结论 Hcy水平与TC、LDL-C相互影响,其次吸烟、饮酒、男性为Hcy水平增高的危险因素,应加强对重点人群的Hcy水平的监控,同时加强对Hcy与血脂关系的进一步研究。Objective To explore the relationship between serum homocysteine(Hcy)and blood lipid in physical examination population and provide the evidence for the mechanism research between Hcy and lipid level.Methods 234 health examinees who came to the health management center of a grade A hospital in Yunnan Province from January 2019 to November 2019 were randomly selected as the subjects.General information,smoking,drinking and diabetes histories of the cases were collected.Plasma homocysteine,blood lipid were measured.Statistical analysis software SPSS 17.0 was used to analyze the level of Hcy and its influencing factors on blood lipid.Results(1)The value of Hcy Md(QR)for males was 12.36(9.90)μmol/L,for females was 7.73(6.40)μmol/L.There was a significant difference between males and females.(2)Smoking history(KW=15.335,P<0.001),drinking history(KW=18.937,P<0.001),LDL-C(r=0.304,P=0.002)、TC(r=0.294,P=0.003)were all correlated with blood Hcy level.Conclusion Total serum cholesterol(TC),low density lipoprotein(LDL-C)are all correlated with blood Hcy level.And smoking,drinking and men are also related to the increase of Hcy level.It is necessary to strengthen the monitoring of the level of Hcy in the risky population and do more research about the relationship between Hcy and blood lipid.

关 键 词：同型半胱氨酸 血脂水平 相关性研究 

分 类 号：R589.3[医药卫生—内分泌] R589.2[医药卫生—内科学]