钛镍合金自膨式支架表面改性研究进展  

Study on Surface Modification of TiNi Alloy Self-expanding Scaffold

作　　者：端木彦涛 李鸣 戴慧 宋金顺 彭东明[1] DUANMU Yan-tao;LI Ming;DAI Hui;SONG Jin-shun;PENG Dong-ming(College of Pharmacy,Hunan University of Chinese Medicine,Hunan Changsha 410208,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208

出　　处：《广州化工》2021年第2期1-4,共4页GuangZhou Chemical Industry

基　　金：长沙市科技计划项目(kq1901092);湖南省自然科学株洲联合基金资助项目(2019JJ60071);湖南省教育厅科学重点研究项目(18A211);2019年湖南省大学生创新训练项目。

摘　　要：钛镍合金(TiNi alloy)因其良好的记忆效应、超弹性和生物相容性被广泛应用于医用植入支架领域,但合金支架在体内释放出Ni离子严重影响了它的安全性,并且支架的植入引起平滑肌细胞增生,容易造成血栓和再狭窄。通过表面氧化、表面涂层、氧化与涂层法结合等方法对合金支架表面改性是解决这一问题的有效途径,本文主要对近年来对TiNi合金的氧化和功能表面涂层改性进行总结并对未来表面改性的发展方向进行展望。Due to its good memory effect,super elasticity and biocompatibility,TiNi alloy is widely used in the field of medical implantable stents.The release of Ni ions in the body seriously affects its biocompatibility,and the implantation of the stent causes smooth muscle cell proliferation,which is tend to cause thrombosis and restenosis.Oxidation,electrolytic polishing,surface coating and other approaches to modify the surface of alloy instruments are effective methods to solve this problem.The research on the oxidation modification and functional surface coating of titanium-nickel alloy in recent years was summarized and the future development direction of surface coating modification was prospected.

关 键 词：钛镍合金 自膨式支架 生物相容性 表面改性 

分 类 号：R541[医药卫生—心血管疾病]