ZnO@ZnFe2O4乳膏的制备工艺及皮肤用药安全性评价  

Preparation Progress of ZnO@ZnFeO Cream and Its Safety Evaluation of Skin Medication

作　　者：李君[1,2] 祖文 刘静[1,2] 王跃武[1,2] 武世奎 LI Jun;ZU Wen;LIU Jing;WANG Yuewu;WU Shikui(Inner Mongolia Medical University,The Center of New Drug Safety Evaluation and Research,Hohhot 010110,China;Inner Mongolia Medical University,Engineering Research Center of New Pharmaceutical Screening,Hohhot 010110,China;Inner Mongolia Medical University,School of Pharmacy,Hohhot 010110,China)

机构地区：[1]内蒙古医科大学新药安全评价研究中心,呼和浩特010110 [2]内蒙古医科大学新药筛选工程研究中心,呼和浩特010110 [3]内蒙古医科大学药学院,呼和浩特010110

出　　处：《中国现代应用药学》2020年第23期2828-2833,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(81503351,81760750);内蒙古医科大学青年创新基金项目(YKD2017QNCX028,YKD2018QNCX023)。

摘　　要：目的研究ZnO@ZnFe2O4乳膏的制备工艺及皮肤用药的安全性。方法采用正交试验方法优选ZnO@ZnFe2O4乳膏的成型工艺;采用Buehler试验,观察豚鼠皮肤接触ZnO@ZnFe2O4乳膏后的过敏情况;将ZnO@ZnFe2O4乳膏单次或多次涂于新西兰兔完整及破损皮肤处,观察药物对皮肤的刺激情况;新西兰兔皮肤单次给药观察药物的急性毒性。结果 ZnO@ZnFe2O4乳膏的最佳工艺条件:乳化剂的用量为6%,乳化时间为20 min,搅拌速度为1 600 r·min^-1,乳化温度为80℃;采用最佳工艺制备的ZnO@ZnFe2O4乳膏对豚鼠皮肤未产生致敏反应,对兔皮肤未产生刺激性,对兔皮肤未引起急性毒性反应。结论 ZnO@ZnFe2O4乳膏经皮给药安全可靠。OBJECTIVE To study the preparation progress and safety of skin medication of ZnO@ZnFe2O4 cream. METHODS Optimizing molding technology of ZnO@ZnFe2O4 cream was optimized by orthogonal experiment method. Buehler test was performed for evaluating the degree of allergy in guinea pig after skin contact with ZnO@ZnFe2O4 cream. Skin irritation was monitored by applying ZnO@ZnFe2O4 cream on the intact and wounded skin of rabbits in single or multiple times. Single administration was given to observe the acute toxicity of ZnO@ZnFe2O4 on New Zealand rabbits. RESULTS The optimized condition was shown below: emulsifier dosage was 6%, emulsifying time was 20 min, stirring speed was 1 600 r·min^-1, emulsifying temperature was 80 ℃. The optimized progress producted-ZnO@ZnFe2O4 cream wasn’t caused allergy in guinea pig, also wasn’t caused side effects and acute toxicity in rabbits’ skin. CONCLUSION Transdermal administration is a safety way for ZnO@ZnFe2O4 cream.

关 键 词：ZnO@ZnFe2O4乳膏 皮肤刺激性 皮肤致敏性 

分 类 号：R943[医药卫生—药剂学]