关木通的回顾性合理用药分析  

Retrospective Analysis of Rational Use of Aristolochia Manshuriensis

作　　者：杨亚蕾[1] 王艳丽[1,2] 桂新景 YANG Yalei;WANG Yanli;GUI Xinjing(Department of Pharmacy,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一附属医院药学部,郑州450000 [2]河南中医药大学药学院,郑州450046

出　　处：《中国现代应用药学》2020年第23期2925-2931,共7页Chinese Journal of Modern Applied Pharmacy

摘　　要：关木通曾因长于镇痛、利尿、消炎等作用,临床应用较为广泛。然而随着中药应用的广泛性,其安全性也备受关注。诸如关木通此类毒效并存的中药,临床不合理应用可导致较高的不良反应事件发生率,本文结合近26年与关木通相关的不良反应文献报道,剖析关木通发生不良反应的根本原因,并从毒性成分角度探讨其发生不良反应的实质,从而对如何促进诸如关木通等马兜铃类中药临床合理用药提出合理化建议。Aristolochia manshuriensis has been widely used in clinical applications because of its effects on analgesia, diuresis and anti-inflammatory. However, with the wide application of traditional Chinese medicine, its safety has become more and more concerned. The traditional Chinese medicines with toxicity and efficacy coexist such as Aristolochiae manshuriensis, the clinical irrational application can lead to a higher incidence of adverse events. This paper combines the literature reports of adverse reactions related to Aristolochiae manshuriensis in the past 26 years to analyze the root causes of adverse reactions in Aristolochiae manshuriensis, and to explore the essence of toxicity from the perspective of toxic components, so as to propose rationalization suggestions on how to promote the rational use of drugs in aristolochic traditional Chinese medicine such as Aristolochiae manshuriensis.

关 键 词：关木通 不良反应 合理用药 马兜铃酸 用药教育 

分 类 号：R285.6[医药卫生—中药学]