生物医用材料表面光引发活性接枝聚合研究新进展  

Progress in Photo-initiated Living Graft Polymerization of Biomaterials

作　　者：孙立伟[1,2] 宋凌杰 栾世方[1,2] 殷敬华[3] Li-wei Sun;Ling-jie Song;Shi-fang Luan;Jing-hua Yin(State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022;College of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026;National Engineering Laboratory of Medical Implant Devices,Weihai 264210)

机构地区：[1]中国科学院长春应用化学研究所高分子物理与化学国家重点实验室,长春130022 [2]中国科学技术大学应用化学与工程学院,合肥230026 [3]威高集团有限公司医用植入器械国家工程实验室,威海264210

出　　处：《高分子学报》2021年第3期223-234,共12页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号51473167,51873213);国家重点研发计划(编号2020YFC1106900);山东省重大科技创新工程(项目号2019JZZY011105);中国科学院院威高计划项目资助.

摘　　要：表面接枝聚合改性已经成为提升生物医用材料性能的最重要方法之一.参比其他活性接枝聚合方法,光引发活性接枝聚合因其独特的优势已被越来越广泛地应用于生物医用材料表面改性.根据光引发剂的类型,目前应用最多的光引发活性接枝聚合的引发体系主要有3种:光引发-转移-终止剂介导的聚合引发体系、二苯甲酮及其衍生物引发体系、硫杂蒽酮类引发体系.本文首先简要介绍了上述3种光引发活性接枝聚合体系的发展历程、接枝机理以及特点.同时结合本课题组相关研究工作,重点论述了光引发接枝聚合技术在3个不同生物医用领域的主要应用:(1)抗菌表面,利用光活性接枝的特点构建层状功能高分子刷,实现表面抗菌功能的阶段性需求.(2)免疫检测表面,使用光活性接枝方法构建层状功能高分子刷,解决检测灵敏度低以及蛋白干扰问题.(3)生物活性分子表面固定,利用可见光活性接枝聚合体系,实现酶在表面的固定化使用以及细胞表面修饰以提高细胞稳定性.最后展望了生物医用材料表面光引发活性接枝聚合研究的发展趋势.Surface modification of biomaterials via graft polymerization has become one of the most important methods to enhance their virtual bio-functionalities.Compared with other living graft polymerization methods,photo-initiated living graft polymerization exhibits superior merits and has been more and more widely used in surface modification of biomaterials.The photoinitiators used for photo-initiated living graft polymerization are mainly categorized into three types:photoiniferter-mediated polymerization(PIMP),benzophenone and its derivatives,and thioxanthones.In this review,the development,graft mechanism and characteristics of the three photo-initiated living graft polymerization systems are briefly introduced.Meanwhile,the applications of photoinitiated graft polymerization in three different biomedical fields are mainly reviewed.i)Antibacterial surface:layered functional polymer brushes constructed by photo-initiated living graft polymerization have been developed to achieve antibacterial function on demand;ii)Immunoassay:layered functional polymer brushes can solve the problem of low detection sensitivity and protein interference;iii)Bioactive molecules fixed on the surface:visible light living graft polymerization system is used to realize the immobilized enzyme on the surface as well as the cell surface modification to improve the stability.Finally,their recent advances in the biomedical fields and the future opportunities and challenges are highlighted.

关 键 词：光活性接枝聚合 表面改性 抗菌 免疫检测 生物活性分子 

分 类 号：TQ316.343[化学工程—高聚物工业] R318.08[医药卫生—生物医学工程]