优思明治疗子宫内膜异位症的疗效与不良反应  

The effect and tolerability of Yasmin on symptomatic endometriosis

作　　者：徐春晓[1] 康程[1] 高伟佳 XU Chunxiao;KANG Cheng;GAO Weijia(Beijing Aerospace General Hospital, Beijing 100076, China)

机构地区：[1]北京航天总医院妇产科,北京100076

出　　处：《西部医学》2021年第1期97-100,共4页Medical Journal of West China

基　　金：北京航天总医院创新基金(20170121)。

摘　　要：目的探讨优思明治疗子宫内膜异位症疗效,为该病的治疗提供新的思路。方法选取2013年6月~2016年8月在北京航天总医院接受治疗的130例子宫内膜异位症患者的临床资料行回顾性分析,所有患者均行腹腔镜保守治疗,术后随机将患者分为GnRH-a组(64例,用GnRH-a治疗)和优思明组(66例,优思明进行治疗),治疗6个月,观察两组患者治疗前后的临床疗效、疼痛程度、子宫体积、月经量、血清激素水平的变化,并记录不良反应情况。结果治疗后,优思明组总有效率显著高于GnRH-a组(P<0.05);与GnRH-a组相比,优思明组患者对慢性疼痛分级和视学模拟评分法(VAS)评分均有显著改善(P<0.05),且优思明组患者子宫体积和月经量均显著减少(P<0.05);与GnRH-a组相比,优思明组患者血清促卵泡激素(FSH)和雌二醇(E2)水平均显著减少(P<0.05);优思明组总不良反应率显著低于GnRH-a组(P<0.05)。结论子宫内膜异位症行腹腔镜保守治疗后应用优思明能够显著提高临床疗效,有效改善患者疼痛症状,减少子宫体积和月经量,并降低不良反应的发生。Objective To evaluate the effectiveness and tolerability of Yasmin on endometriosis patient.Methods The clinical data of 130 patients with endometriosis treated in Beijing Aerospace General Hospital from June 2013 to August 2016 were retrospectively analyzed.All patients were treated with laparoscopic conservative treatment.After operation,the patients were randomly divided into GnRH a group(64 cases,treated with GnRH a)and Yasmin group(66 cases,treated with Yasmin).After treatment for 6 months,the patients in the two groups were observed before and after treatment The changes of clinical efficacy,pain degree,uterine volume,menstrual volume,serum hormone level,and adverse reactions were recorded.Results After treatment,the total effective rate of the yousiming group was significantly higher than that of the GnRH-a group(P<0.05).Compared with the GnRH-a group,the chronic pain grading and VAS score of the Yasmin group were significantly improved(P<0.05).Compared with the GnRH-a group,the uterine volume and menstrual volume of the Yasmin group were significantly reduced(P<0.05).Compared with the GnRH-a group,the serum FSH and E2 levels of the Yasmin group were significantly reduced The total adverse reaction rate of Yasmin group was significantly lower than that of GnRH-a group(P<0.05).Conclusion The application of Yasmin after laparoscopic conservative treatment of endometriosis can significantly improve the clinical efficacy,effectively improve the patient's pain symptoms,reduce uterine volume and menstrual volume,and reduce the occurrence of adverse reactions,which can be widely applied in clinical practice.

关 键 词：子宫内膜异位症 优思明 临床疗效 血清激素水平 不良反应 

分 类 号：R711.71[医药卫生—妇产科学]