维持性血液透析患者血清铁蛋白及CD4^+T CD8^+T细胞与腹主动脉钙化评分的关系  

Relationship between serum ferritin,CD4^+T cells,CD8^+T cells and abdominal aortic calcification scores in patients undergoing maintenance hemodialysis

作　　者：吴艳 李永超 钟杰[2] 苏利 唐山宝 WU Yan;LI Yongchao;ZHONG Jie;SU Li;TANG Shanbao(Department of Critical Cone Medicine,Panzhihua Integrated Traditional Chinese and Westen Medicine Hospital,Panzhilhua 617000,Sichuan,China;Department of Clrology, Panzhihua Integrated Traditional Chinese and Westen Medicine Hospital,Panzhihua 617000,Sichuan, China)

机构地区：[1]攀枝花市中西医结合医院重症医学科,四川攀枝花617000 [2]攀枝花市中西医结合医院肾内科,四川攀枝花617000

出　　处：《西部医学》2021年第1期120-123,129,共5页Medical Journal of West China

摘　　要：目的探讨维持性血液透析患者血清铁蛋白、CD4^+T、CD8^+T细胞与腹主动脉钙化评分之间的关系。方法将我院2017年9月~2019年9月期间收治的100例维持性血液透析患者设为研究组,选取同期体检健康者52例设为对照组,均进行血清铁蛋白、CD4^+T、CD8^+T细胞水平以及腹主动脉钙化评分测定,依据腹主动脉钙化评分将研究组分为钙化组(n=47)与未钙化组(n=53)。比较3组血清铁蛋白、CD4^+T、CD8^+T细胞水平以及腹主动脉钙化评分,血清铁蛋白、CD4^+T、CD8^+T细胞水平与腹主动脉钙化评分相关性,3组不良心血管发生率,血清铁蛋白、CD4^+T、CD8^+T细胞水平与腹主动脉钙化评分对不良心血管事件预测价值。结果钙化组与未钙化组血清铁蛋白、CD4^+T细胞、腹主动脉钙化评分高于对照组,CD8^+T细胞低于对照组(P<0.05);钙化组血清铁蛋白、CD4^+T细胞、腹主动脉钙化评分高于未钙化组,CD8^+T细胞低于未钙化组,差异有统计学意义(P<0.05);Pearson相关性分析显示,血清铁蛋白、CD4^+T细胞与腹主动脉钙化评分呈正相关(r=0.446,0.521,P<0.05),CD8^+T细胞与腹主动脉钙化评分负相关(r=0.624,P<0.05);钙化组、未钙化组以及对照组不良心血管事件发生率分别为57.45%、33.96%及1.92%,3组之间比较差异有统计学意义(P<0.05);ROC曲线显示血清铁蛋白、CD4^+T、CD8^+T细胞水平与腹主动脉钙化评分用于预测不良心血管事件AUC分别为0.612、0.772、0.732、0.803。结论维持性血液透析患者血清铁蛋白及CD4^+T、CD8^+T细胞与腹主动脉钙化评分关系密切,可用于预测患者不良心血管事件发生。Objective To explore the relationship between serum ferritin,CD4^+T cells,CD8^+T cells and abdominal aortic calcification scores in patients undergoing maintenance hemodialysis.Methods 100 patients undergoing maintenance hemodialysis and 52 healthy individuals completing health check-ups in the hospital during the period from September 2017 to September 2019 were selected as the study group(n=100)and the control group(n=52).The levels of serum ferritin,CD4^+T cells and CD8^+T cells,and abdominal aortic calcification scores were measured.Patients in the study group were divided into the calcification group(n=47)and the non-calcification group(n=53)according to the abdominal aortic calcification score.The levels of serum ferritin,CD4^+T cells and CD8^+T cells,and abdominal aortic calcification scores in the three groups were compared.The correlation between serum ferritin,CD4^+T cells,CD8^+T cells and abdominal aortic calcification scores was analyzed,and the incidence rates of adverse cardiovascular events in the three groups were recorded.The value of above indexes in predicting adverse cardiovascular events was analyzed.Results The scores of serum ferritin,CD4+T cells and abdominal aorta calcification in calcified and non calcified groups were higher than those in control group,and CD8^+T cells were lower than those in control group(P<0.05).The scores of serum ferritin,CD4^+T cells and abdominal aorta calcification in calcified group were higher than those in non calcification group,while CD8+cells in calcified group were lower than those in non calcification group(P<0.05).Pearson correlation analysis showed that serum ferritin and CD4^+T cells were positively correlated with abdominal aortic calcification score(r=0.446,0.521,P<0.05),while CD8^+T cells were negatively correlated with abdominal aortic calcification score(r=0.624,P<0.05).The incidence of adverse cardiovascular events was 57.45%,33.96%and 1.92%in calcified group,non calcified group and control group,respectively.There was significant difference amo

关 键 词：维持性血液透析 铁蛋白 CD4^+T CD8^+T 腹主动脉钙化评分 

分 类 号：R473.5[医药卫生—护理学]