血清相关炎症因子表达水平与老年膝关节骨性关节炎病情严重程度的相关性  

Analysis of correlation between expression levels of serum IL-17,TNF-α,TGF-β1 and TIMP-1 and disease severity of elderly knee osteoarthritis

作　　者：姚力偀[1] 唐洁[1] 郑洁[1] 吴泳华 胡冬[1] 陈刚[1] YAO Liying;TANG Jie;ZHENG Jie;WU Yonghua;HU Dong;CHEN Gang(Department of Clinical Laboratory, Mianyang Central Hospital, Mianyang 621000, Sichuan, China)

机构地区：[1]绵阳市中心医院检验科,四川绵阳621000

出　　处：《西部医学》2021年第1期144-147,共4页Medical Journal of West China

基　　金：绵阳市中心医院孵化课题(2019FH05)。

摘　　要：目的探讨血清白介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)、基质金属蛋白酶组织抑制剂-1(TIMP-1)表达水平与老年膝关节骨性关节炎(KOA)病情严重程度的相关性。方法回顾性分析2019年1月~2019年12月我院收治的148例老年KOA患者临床资料。所有患者均行X线检查并行KL(kellgren Lawrence)分级,根据分级结果将患者分为病情轻中度组和重度组,比较不同病情严重程度患者组间IL-17、TNF-α、TGF-β1和TIMP-1水平差异,采用spearman法分析上述指标水平与KL分级的关系,利用ROC曲线评估上述指标对重度老年KOA的诊断效能。结果两组患者年龄、性别、体质量差异均无统计学意义(P>0.05);轻中度组IL-17、TNF-α水平均低于重度组(P<0.05),TIMP-1、TGF-β1高于重度组(P<0.05);Spearman相关性分析显示,KL分级与IL-17、TNF-α呈正相关(P<0.05),与TGF-β1、TIMP-1呈负相关(P<0.05);ROC曲线分析显示,IL-17、TNF-α、TGF-β1、TIMP-1均能诊断重度KOA(P<0.05),其中TGF-β1的AUC最高。结论血清IL-17、TNF-α、TGF-β1、TIMP-1表达水平与老年KOA患者病情严重程度均有不同程度相关性,可作为临床病情严重程度评估的辅助指标。Objective To explore the correlation between expression levels of serum interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1)and tissue inhibitor of metalloproteinase-1(TIMP-1)and disease severity of elderly knee osteoarthritis(KOA).Methods The clinical data of 148 elderly KOA patients admitted between January 2019 and December 2019 were retrospectively analyzed.All patients underwent X-ray examination and were given KL(kellgren Lawrence)classification.According to the classification results,the patients were divided into mild-to-moderate group and severe group.The levels of IL-17,TNF-α,TGF-β1 and TIMP-1 were compared among patients with different disease severity.Spearman method was used to analyze the relationship between laboratory indexes levels and KL classification,and ROC curve was drawn to evaluate the diagnostic efficacy of above indexes on severe elderly KOA.Results There were no significant differences in the age,gender and body mass between KOA patients in mild-to-moderate group and severe group(P>0.05).The levels of IL-17,TNF-αin mild-to-moderate group were lower than those in severe group(P<0.05)while the TGF-β1,TIMP-1 was higher than that in severe group(P<0.05).Spearman correlation analysis showed that KL classification was positively correlated with IL-17,TNF-α(P<0.05),and was negatively correlated with TGF-β1,TIMP-1(P<0.05).ROC curve showed that IL-17,TNF-α,TGF-β1 and TIMP-1 could diagnose severe KOA(P<0.05),and the AUC of TGF-β1 was the highest.Conclusion The expression levels of serum IL-17,TNF-α,TGF-β1 and TIMP-1 have different degrees of correlation with disease severity of elderly KOA patients,and can be used as auxiliary indicators for clinical disease evaluation.

关 键 词：膝关节骨性关节炎 炎症因子 转化生长因子-Β1 基质金属蛋白酶组织抑制剂-1 相关性 

分 类 号：R684.3[医药卫生—骨科学]