经鼻高流量吸氧对免疫功能不全伴呼吸衰竭患者预后影响的meta分析  

The effect of nasal high-flow oxygen on the prognosis of patients with immunocompromised respiratory failure:a meta-analysis of trials

作　　者：张雪晴[1] 童丽[1] ZHANG Xueqing;TONG Li(The First People's Hospital of Changde,Changde 415000,China)

机构地区：[1]湖南省常德市第一人民医院,常德415000

出　　处：《当代护士（上旬刊）》2021年第1期4-10,共7页Modern Nurse

基　　金：湖南省常德市指导性项目(2016ZD22)。

摘　　要：目的采用Meta分析评价经鼻高流量吸氧在免疫功能不全伴呼吸衰竭患者中应用的有效性。方法检索中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库、中文科技期刊数据库、Pubmed及Cochrane Library,检索时间从建库至2019年1月。收集在免疫功能不全伴呼吸衰竭患者中应用经鼻高流量吸氧(HFNC)的临床研究,采用RevMan 5.3软件对收集的资料进行Meta分析评价。结果共纳入9项研究,包括1848例患者,其中HFNC组893例,对照组955例;对两组患者一般资料进行系统分析显示,HFNC组的男性患者数量显著高于对照组(P<0.05);两组患者在28 d死亡率、ICU死亡率、插管率及ICU停留时间上比较,差异无统计学意义(P>0.05);在ICU停留时间方面排除一项研究进行敏感性分析后显示,相比对照组,HFNC组ICU停留时间显著增高,差异具有统计学意义(P<0.001)。结论HFNC应用于免疫功能不全伴呼吸衰竭患者在死亡率、插管率以及ICU停留时间方面并未显示出优势,其有效性还需要大量的高质量的临床研究来进一步证实。Objective To evaluate the effectiveness of nasal high-flow oxygen in patients with immunocompromised respiratory failure.Methods The Chinese Academic Journal Full-text Database(CNKI),China Biomedical Literature Database(CBM),Wanfang Database,Chinese Science and Technology Periodical Database,Pubmed and Cochrane Library were searched.The search time was from the establishment of the database to January 2019.Clinical studies using nasal high-flow oxygen inhalation(HFNC)in patients with immunocompromised respiratory failure were collected.The collected data were evaluated by Meta analysis using RevMan 5.3 software.Results A total of 9 studies were included,including 1848 patients,including 893 patients in the HFNC group and 955 patients in the control group.A systematic analysis of the general data of the two groups showed that the number of male patients in the HFNC group was significantly higher than that in the control group(P<0.05).There was no significant difference in 28-day mortality,ICU mortality,intubation rate,and ICU stay time between the two groups(P>0.05).Excluding a study in the ICU stay time,the sensitivity analysis showed that the ICU stay time of the HFNC group was significantly increased,and the difference was statistically significant(P<0.001).Conclusion HFNC has not shown advantages in terms of mortality,intubation rate,and ICU stay in patients with immunocompromised respiratory failure,and its effectiveness requires further high-quality clinical studies to further confirm.

关 键 词：经鼻高流量吸氧 免疫功能不全 呼吸衰竭 预后 META分析 

分 类 号：R47[医药卫生—护理学]