国产生物可吸收冠状动脉支架的研究现状  

Research status of domestic bioabsorbable coronary artery stents

作　　者：李崇崇 王硕[1] 万辰杰 王春仁[1] LI Chongchong;WANG Shuo;WAN Chenjie;WANG Chunren(National Institutes for Food and Durg Control,Beijing 102629)

机构地区：[1]中国食品药品检定研究院,北京102629

出　　处：《北京生物医学工程》2021年第1期95-100,共6页Beijing Biomedical Engineering

摘　　要：心血管介入治疗技术是治疗心血管疾病的重要手段,永久金属支架虽然可以为冠脉狭窄提供支撑,但其在血管内长期存留可引起血管的慢性损伤,后期可造成血管中层萎缩、动脉瘤形成以及反应性内膜增生,最终导致血管再狭窄。随着科学技术的发展和实验的探索,生物可吸收支架正在逐步替代金属永久支架,成为冠状动脉介入治疗发展的新方向。国产冠脉支架的发展经历了模仿、改进、创新的漫长历程,目前新型的生物可吸收冠状动脉支架已经取得了可喜的阶段性研究成果。本文综述了几种国产新型生物可吸收支架的发展情况,归纳其各自的特点和临床试验结果,分析了当前的问题,并对未来的发展做了展望。Cardiovascular interventional therapy is an important means to treat cardiovascular diseases.Although permanent metal stent can provide support for coronary artery stenosis,its long-term retention in the vessel can cause chronic vascular damage,which can cause vascular medial atrophy,aneurysm formation and reactive intimal hyperplasia,eventually leading to vascular restenosis.With the development of technology and experimental exploration,bioabsorbable stents are gradually replacing metal permanent stents and become a new direction of coronary intervention.The development of domestic coronary stents has experienced a long process of imitation,improvement and innovation.At present,the new bioabsorbable coronary stents have achieved gratifying results.This paper reviews the development of several new domestic bioabsorbable stents,summarizes their respective characteristics and clinical trials,analyzes the current problems,and prospects the future development.

关 键 词：生物可吸收支架 冠状动脉 临床试验 器械设计 经皮冠状动脉介入治疗 

分 类 号：R318.08[医药卫生—生物医学工程]