滋肾养肝化瘀颗粒对乙肝肝硬化患者肝纤维化指标的影响  

Effect of Zishen Yanggan Huayu Granules on Hepatic Fibrosis Indexes in Patients with Hepatitis B Cirrhosis

作　　者：张广业[1] 张刚 ZHANG Guangye;ZHANG Gang(Shandong University of Traditional Chinese Medicine Affiliated Rizhao City Hospital of Traditional Chinese Medicine,Hepatology,Rizhao 276800,China)

机构地区：[1]山东中医药大学附属日照市中医医院肝病科,日照276800

出　　处：《世界中医药》2021年第1期142-147,共6页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81673926)。

摘　　要：目的:观察滋肾养肝化瘀颗粒治疗肝肾阴虚型乙肝肝硬化临床疗效。方法:选取2015年7月至2018年7月山东中医药大学附属日照市中医医院收治的肝肾阴虚型乙肝肝硬化患者110例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组55例,对照组服用乙肝养阴活血颗粒,观察组服用滋肾养肝化瘀颗粒,2组均治疗6个月,治疗前后观察患者肝纤维化五项、肝脏硬度。结果:治疗后观察组PCⅢ、C-Ⅳ、HA水平显著低于对照组(P<0.05),观察组LSM检测值低于对照组(P<0.01)。结论:滋肾养肝化瘀颗粒治疗肝肾阴虚型乙肝肝硬化具有较好的抗肝纤维化及肝硬化效果。Objective:To observe the clinical effect of Zishen Yanggan Huayu Granules in treating hepatitis B cirrhosis of the deficiency of yin of liver and kidney.Methods:A total of 110 patients with hepatitis B cirrhosis of the deficiency of yin of liver and kidney were divided into an observation group(n=55)and a control group(n=55)randomly.The patients in observation group were treated with Zishen Yanggan Huayu Granules,and the patients in the control group were treated with Yinyin Yanggan Huoxue Granules.6 months of a course.The changes of hepatic fibrosis 4 and liver stiffness measurement(LSM)were compared between 2 groups before and after treatment.Results:The levels of PC III and C-IV in observation group were significantly lower than those in control group after treatment(P<0.01),the LSM detection value of the observation group was lower than that of the control group(P<0.01).Conclusion:Zishen Yanggan Huayu Granules have better anti-hepatic fibrosis and cirrhosis effect.

关 键 词：滋肾养肝化瘀颗粒 肝肾阴虚型 乙肝肝硬化 肝纤维化 

分 类 号：R512.6[医药卫生—内科学]