基于中医传承系统探索丁治国治疗桥本氏病用药规律研究  

Exploration of the Medication Rule for the Use of Ding Zhiguo in the Treatment of Hashimoto′s Disease Based on the Inheritance System of Traditional Chinese Medicine

作　　者：李心爱 祁烁 陈晓珩 李哲 李会龙 张磊 黄盛 付金香 丁治国[1] LI Xin′ai;QI Shuo;CHEN Xiaoheng;LI Zhe;LI Huilong;ZHANG Lei;HUANG Sheng;FU Jinxiang;DING Zhiguo(The First Clinical Medical College of Beijing University of Chinese Medicine/Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学第一临床医学院/北京中医药大学东直门医院,北京100020

出　　处：《世界中医药》2021年第1期167-172,176,共7页World Chinese Medicine

基　　金：北京中医药大学青年教师项目(2019-JYB-JS-057)——基于NIM网络研究疏肝理气方治疗肝郁气滞型的桥本氏甲状腺炎的临床疗效及其作用机制;北京中医药大学新奥基金项目(2017-XAJLJJ-017)——基于古籍医案、医论梳理胃癌中医辨证论治理论与用药规律的研究。

摘　　要：目的:处方是中医临床诊疗过程的最终体现,该文借助中医传承辅助系统分析丁治国教授治疗慢性淋巴细胞性甲状腺炎的组方用药规律。方法:通过整理近2017年至今中药治疗单纯性慢性淋巴细胞性甲状腺炎的处方为数据源,筛选出符合要求的109首初诊治疗慢性淋巴细胞性甲状腺炎的新处方,并建立数据库,运用频数统计、关联规则等进行数据挖掘,对核心药物及其归经、性味、组方规律等进行分析研究。结果:处方中涉及中药84味,处方中药物出现频次≥75次的药物得到13个,演化得到核心组合6个,新处方3个;核心药物主要归经肺、脾二经,性味分别为苦、甘。结论:对丁治国教授治疗CLT的用药规律进行探索与总结,为中医药治疗CLT开拓了新思路,对桥本患者的治疗提供了新的方案。Objective:Prescription is the final embodiment of traditional Chinese medicine(TCM)clinical diagnosis and treatment process.This paper analyzes the prescription law of Professor DING Zhiguo in the treatment of chronic lymphocytic thyroiditis with the aid of TCM inheritance system.Methods:By sorting out the prescriptions of traditional Chinese medicine for the treatment of simple chronic lymphocytic thyroiditis from 2017 to the present as a data source,109 new prescriptions for the treatment of chronic lymphocytic thyroiditis that meet the requirements were screened out,and a database was established.Frequency statistics and correlation were used for data mining.The core drugs and their meridian,nature and flavor,and prescription rules were analyzed and studied.Results:A total of 84 Chinese medicines were involved in the prescription.The number of prescription drugs with a frequency of≥75 times received 13 drugs,6 core combinations and 3 new prescriptionsere were evolved;the core drugs mainly belonged to the lung and spleen channels,and their nature and flavor were bitter and sweet.Conclusion:The drug law of Professor DING Zhiguo in the treatment of CLT were explored and summarized,opening up new ideas for the treatment of CLT with TCM,and to provide a new scheme for the treatment of Hashimoto patients.

关 键 词：慢性淋巴细胞性甲状腺炎 用药规律 中医传承辅助系统 中医药 

分 类 号：R242[医药卫生—中医临床基础]