下腰痛患者针刺治疗脑功能网络的小世界拓扑特性  

Small-world topological characteristics of the brain functional networks in patients with low back pain which treated by acupuncture

作　　者：贾润慧[1] 汪新柱[1] 陈晓飞[1] 董馥闻 温玉蓉 周晟[1] JIA Runhui;WANG Xinzhu;CHEN Xiaofei;DONG Fuwen;WEN Yurong;ZHOU Sheng(Department of Radiology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou,730050,China)

机构地区：[1]甘肃省中医院放射影像科,甘肃兰州730050 [2]兰州大学第二医院介入科,甘肃兰州730030

出　　处：《中国中西医结合影像学杂志》2021年第1期24-26,共3页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：甘肃省青年科技基金计划项目(17JR5RA049)。

摘　　要：目的:利用静息态fMRI探讨针刺治疗下腰痛患者脑功能网络的小世界拓扑特性。方法:纳入下腰痛患者20例,针刺委中及大肠俞穴,分别于治疗前及治疗14 d后行静息态fMRI扫描,构建全脑功能网络,分析针刺前后聚类系数(CP)、最短路径长度(LP)、局部信息交换效率(Elocal)和全局信息交换效率(Eglobal)的拓扑特性变化。采用视觉模拟疼痛评分(VAS)、日本骨科协会(JOA)下腰痛疗效表评定针刺的临床疗效。结果:VAS评分提示针刺治疗后疼痛症状缓解。JOA疗效表提示针刺治疗下腰痛有效。脑网络小世界拓扑特性显示,稀疏度在0.2~0.3内,治疗前后的CP、Elocal、Eglobal与阈值呈负相关,LP与阈值呈正相关,且治疗前CP值及Elocal值明显低于治疗后,差异均有统计学意义(均P<0.05)。结论:下腰痛患者针刺治疗前CP值及Elocal值均明显低于治疗后,针刺前后全脑功能网络的小世界拓扑特性发生变化,有助于探索针刺的治疗机制。Objective:To explore the topological characteristics of small-world of the brain functional networks in patients with low back pain which treated by acupuncture.Methods:Totally 20 patients with low back pain were involved.With the treatment of acupuncture at Weizhong and Dachangyu acupoints from the same experienced acupuncturist.Resting-state fMRI data were acquired respectively before and after 14 days treatment,and the whole brain functional networks were constructed.The small-world topological characteristics including CP,LP,Elocal,Eglobal were analyzed before and after acupuncture.The visual analogue score(VAS)and JOA low back pain table were used to evaluate the clinical efficacy of acupuncture.Results:VAS scores showed relief of pain symptoms of low back pain by acupuncture.JOA scores suggested that acupuncture was effective in treating low back pain.Within the range of 0.2≤sparsity≤0.3,the CP,Elocal and Eglobal were negatively correlated with the threshold,while LP was positively correlated with the threshold before and after treatment.The CP and Elocal increased obviously after treatment,and the differences were significant(both P<0.05).Conclusions:The CP and Elocal increase after acupuncture treatment,and the small-world topological characteristics of whole brain functional network vary before and after acupuncture,which is helpful to explore the mechanism of acupuncture treatment.

关 键 词：腰痛 磁共振成像 脑功能网络 小世界网络 拓扑 

分 类 号：R246.9[医药卫生—针灸推拿学]