宫腔镜下切除术联合复方公英散治疗宫腔粘连疗效及患者血清白细胞介素及肿瘤坏死因子变化  

The curative effect of hysteroscopic adhesion resection combined with compound Gonging powder for treating women with intrauterine adhesion,and the changes of serum IL-6,IL-10 and TNF-α

作　　者：袁风玲 贾淑慧[2] 江源[3] YUAN Finagling;JIA Chuhui;JIANG Yuan(The First People's Hospital of Xining,Qinghai Province,810000;Qinghai Provincial Hospital of Traditional Chinese Medicine;Nanjing Gulon Hospital)

机构地区：[1]青海省西宁市第一人民医院,810000 [2]青海省中医院 [3]江苏省南京市鼓楼医院

出　　处：《中国计划生育学杂志》2021年第1期25-27,32,共4页Chinese Journal of Family Planning

摘　　要：目的:研究宫腔镜宫腔粘连切除术联合复方公英散对宫腔粘连(IUA)疗效及患者血清白细胞介素-6(IL-6)、IL-4、IL-10、肿瘤坏死因子-α(TNF-α)变化。方法:选取本院2017年1月-2019年2月收治的宫腔镜宫腔粘连切除术患者100例,分为两组各50例。术后对照组给予常规药物治疗,观察组在对照组基础上给予复方公英散治疗,比较两组临床疗效。结果:治疗后观察组子宫内膜厚度(6.1±1.6mm)高于对照组,IL-4(17.42±3.21ng/ml)、IL-10(20.34±4.87ng/ml)水平高于对照组,IL-6(32.12±8.12ng/L)、TNF-α(39.41±5.84ng/L)水平低于对照组(均P<0.05);月经改善情况优于对照组,半年内妊娠率(38.0%)高于对照组(均P<0.05)。结论:宫腔镜宫腔粘连切除术联合复方公英散治疗IUA可抑制调节炎症因子的表达,促进子宫内膜的生长,改善术后月经情况。Objective:To explore the curative effect of hysteroscopy adhesion resection combined with compound Gonging powder for treating women with intrauterine adhesion(IUA),and to study the changes of the levels of serum interleukin 6(IL-6),interleukin 10(IL-10),and tumor necrosis factor-α(TNF-α).Methods:From January 2017 to February 2019,100 women with IUA after hysteroscopy adhesion resection were selected and divided into observation group and control group(50 cases in each group).The women in the control group were treated with routine treatment after operation,and the women in the observation group were treated with Gonging powder except to routine treatment.The clinical efficacy of women was compared between the two groups.Results:The endometrial thickness and the levels of IL-4 and IL-10 of women in the observation group were 6.1±1.6mm,17.42±3.21ng/ml,and 20.34±4.87 ng/ml,respectively,which were significant higher than those of women in the control group,while the levels of IL-6(32.12±8.12ng/L)and TNF-α(39.41±5.84ng/L)of women in the observation group were significant lower than those of women in the control group(all P<0.05).The improvement of menstruation rate of women within half a year after treatment in the observation group(38.0%)was significant better than that of women in the control group(P<0.05).Conclusion:The hysteroscopy adhesion resection combined with compound Gonging powder for treating women with intrauterine adhesion can inhibit the expression of inflammatory factors,promote the growth of endometrial,and improve the menstrual condition after operation.

关 键 词：宫腔粘连 宫腔粘连切除术 复方公英散 炎症因子 月经恢复 

分 类 号：R713.4[医药卫生—妇产科学]