TAT、PIC、TM、tPAI-C预测孕中晚期孕妇深静脉血栓价值  

Value of detection of TAT, PIC, TM and tPAI-C for predicting deep venous thrombosis of women during the second and third trimester of pregnancy

作　　者：王宇[1] 孙秋瑾[1] 张雯雯 刘美玲 WANG Yu;SUN Qiujing;ZHANG Wenwen;LIU Meiling(Chaoyang District Maternal and Child Health Care Hospital,Beijing,100021)

机构地区：[1]北京市朝阳区妇幼保健院,100021

出　　处：《中国计划生育学杂志》2021年第1期79-83,211,共6页Chinese Journal of Family Planning

基　　金：北京市科委课题(D161100000416001)。

摘　　要：目的:探讨血浆中凝血酶抗凝酶复合物(TAT)、纤溶酶-抗纤溶酶复合物(PIC)、血栓调节蛋白(TM)、组织型纤溶酶原激活抑制复合物(tPAI-C)检测对孕中晚期深静脉血栓(DVT)的预测价值。方法:选择2019年1月-2019年9月于本院产科建立完整产前检查档案并计划分娩的孕中晚期DVT孕妇48例(DVT组)和健康孕妇54例(对照组),比较两组基线资料、实验室指标(TAT、PIC、TM、tPAI-C),多因素回归分析发生DVT独立影响因素;绘制受试者ROC曲线,确定最佳截断点和预测效能。结果:DVT组孕晚期PLT低于孕中期,FIB、PT、TAT、PIC、TM、tPAI-C值高于孕中期(P<0.05),对照组孕中期和孕晚期上述各指标无差异(P>0.05);DVT组孕晚期、孕中期FIB、PT低于对照组,TAT、PIC、TM、tPAI-C值高于对照组(均P<0.05)。TAT、PIC、TM、tPAI-C值是孕中晚期孕妇发生DVT独立影响因素(P<0.05)。PIC、TM、tPAI-C联合检测对孕中晚期孕妇发生DVT的预测价值最高(P<0.05)。结论:TAT、PIC、TM、tPAI-C为影响孕中晚期DVT发生的独立预测因子,联合检测可为临床早期诊治提供参考。Objective:To investigate the value of detection of plasma thrombin-antithrombin complex(TAT),plasmin-α2-antiplasmin complex(PIC),thrombomodulin(TM),tissue-type plasminogen activator-inhibitor complex(tPAI-C)for predicting deep venous thrombosis(DVT)of women during the second and third trimester of pregnancy.Methods:48 women with DVT during the second and third trimester of pregnancy were enrolled in study group,and 54 normal pregnant women during the second and third trimester of pregnancy were enrolled in control group from January 2019 to September 2019.The baseline data and the levels of TAT,PIC,TM,and tPAI-C of women were compared between the two groups.The independent influencing factors of DVT were analyzed by multivariate regression analysis.The ROC curve was used to determine the best cutoff point and prediction efficiency.Results:In the study group,PLT level of women during the third trimester of pregnancy was significant lower than that of women during the second trimester of pregnancy,but the levels of FIB,PT,TAT,PIC,TM,and TPAI-C of women during the third trimester of pregnancy were significant higher(P<0.05).There were no significant different in the levels of PLT,FIB,PT,TAT,PIC,TM,and TPAI-C of women in the control group between the second and the third trimester of pregnancy(P>0.05).The FIB and PT levels of women in the study group during the second and third trimester of pregnancy were significant lower than those of women in the control group,while the levels of TAT,PIC,TM and TPAI-C were significant higher(all P>0.05).TAT level,PIC level,TM level,and TPAI-C level were independent influencing factors of DVT occurrence of women during the second and third trimester of pregnancy(P<0.05).The value of combined detection of PIC,TM and TPAI-C for predicting DVT of women during the second and third trimester of pregnancy was the highest(P<0.05).Conclusion:TAT level,PIC level,TM level,and TPAI-C level are independent influencing factors of DVT occurrence of women during the second and third trimester of

关 键 词：孕中晚期 深静脉血栓 凝血酶抗凝酶复合物 纤溶酶-抗纤溶酶复合物 血栓调节蛋白 组织型纤溶酶原激活抑制复合物 预测价值 

分 类 号：R714.252[医药卫生—妇产科学]