卵巢低储备患者卵泡液中AMH、透明质酸水平及其与获卵结果关系  

Levels of AMH and hyaluronic acid in follicular fluid of women with low ovarian reserve and their relevant to the results of oocyte retrieval

作　　者：丁玉玲[1] 安红军[1] 肖葡萄 Ding Yuling;An Hongjun;Xiao Putao(Jiyuan Maternal and Child Health Care Hospital,Henan Province,459000)

机构地区：[1]河南省济源市妇幼保健院,459000

出　　处：《中国计划生育学杂志》2021年第1期110-113,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨卵巢低储备患者卵泡液中抗苗勒管激素(AMH)、透明质酸水平及其与获卵结果。方法:选取2018年1月-2019年3月本院收治的不孕妇女190例,根据卵巢储备功能评定标准分为卵巢低储备组(n=42)和正常储备组(n=148),检测并比较两组卵泡液AMH和透明质酸水平。结果:低储备组卵泡液AMH(1.22±0.32ng/ml)、透明质酸(280.92±68.82g/L)及获卵数(3.3±0.7枚)均低于正常储备组(P<0.05);卵泡液AMH、透明质酸与获卵数呈正相关(r=0.618和0.358,P<0.05);卵泡液AMH、透明质酸预测卵巢低储备功能的ROC曲线下面积分别为0.934和0.808(P<0.05),截断值分别为1.73 ng/ml和305.50g/L,灵敏性分别为91.2%和82.5%,特异性分别为90.0%和78.0%。结论:卵泡液AMH、透明质酸水平与获卵数有一定相关性,在预测卵巢储备功能方面有一定应用价值。Objective:To investigate the levels of antimullerian hormone(AMH)and hyaluronic acid in follicular fluid of women with low ovarian reserve,and to study their relevant to the results of oocyte retrieval.Methods:190 infertile women were selected and divided into group A(42 low ovarian reserve)and group B(148 women with normal ovarian reserve)according to the ovarian reserve function evaluation criteria from January 2018 to March 2019.The AMH and hyaluronic acid levels in follicular fluid of women were measured and compared between the two groups.Results:The AMH level(1.22±0.32ng/ml),the hyaluronic acid level(280.92±68.82g/L),and the number of eggs retrieval(3.3±0.7)of women in group A were all significant lower than those of women in group B(P<0.05).The levels of AMH and hyaluronic acid in follicular fluid were positively correlated with the number of eggs retrieval(r=0.618 and 0.358,P<0.05).The area under ROC curve of the levels of AMH and hyaluronic acid in follicular fluid for predicting low ovarian reserve were 0.934 and 0.808,respectively(P<0.05),and which’s cut off values were 1.73 ng/ml and 305.50 g/L,respectively.The sensitivity of the levels of AMH and hyaluronic acid in follicular fluid for predicting low ovarian reserve were 91.2%and 82.5%,and the specificity of them were 90.0%and 78.0%,respectively.Conclusion:The levels of AMH and hyaluronic acid in follicular fluid of women with low ovarian reserve have certain relevant to their oocyte retrieval,which has some application value for predicting ovarian reserve function.

关 键 词：卵巢储备功能 卵泡液 抗苗勒管激素 透明质酸 获卵数 

分 类 号：R714.8[医药卫生—妇产科学]