孕妇血清VEGF和sFlt-1联合多普勒超声诊断胎盘植入效果  

Effect of serum levels of vascular endothelial growth factor and sFlt-1 combined with Doppler ultrasonography for diagnosing placental implantation of pregnant women

作　　者：周冰峰[1] 阚长利[1] 侯敬[1] 付久园[1] ZHOU Bingfeng;KAN Changli;HOU Jing;FU Jiuyuan(Southern branch of affiliated Hospital of Chengde Medical College,Chengde,Hebei Province,067000)

机构地区：[1]承德医学院附属医院南院,067000

出　　处：《中国计划生育学杂志》2021年第1期114-117,共4页Chinese Journal of Family Planning

基　　金：河北省承德市科学技术研究与发展计划任务书(201804A018)。

摘　　要：目的:探究血清血管内皮生长因子(VEGF)和可溶性血管生长因子受体(sFlt-1)联合多普勒超声检查诊断孕妇产前胎盘植入价值。方法:选取2016-2018年本院分娩的孕妇,在孕28周取静脉血,酶联免疫吸附法检测血清VEGF和sFlt-1水平,根据产后胎盘病理结果作为诊断胎盘植入金标准,分为胎盘植入组和非胎盘植入组,分析不同组血清VEGF、sFlt-1水平,各种检测方法诊断胎盘植入效果。结果:非胎盘植入组血清VEGF水平(249.37±18.23 pg/ml)低于胎盘植入组(335.24±16.95 pg/ml),sFlt-1水平(2939.93±28.99 pg/ml)高于胎盘植入组(2483.56±28.67 pg/ml),孕妇孕晚期血清VEGF、sFlt-1水平高于孕中期和孕早期,孕中期高于孕早期,胎盘植入组植入深者高于植入浅者(均P<0.05)。血清两项指标联合彩色超声检测与病理诊断相符率为88.6%,诊断灵敏度87.9%,漏诊率11.4%。结论:血清VEGF、Flt-1联合多普勒超声检查诊断孕妇产前胎盘植入有较好的临床指导意义。Objective:To explore the value of serum levels of vascular endothelial growth factor(VEGF)and sFlt-1 combined with Doppler ultrasonography for diagnosing placental implantation of pregnant women.Methods:Pregnant women were selected in this study randomly from 2016 to 2018.The venous blood of these women during 28 gestational weeks were collected,and their levels of serum VEGF and sFlt-1 were detected by ELISA.These women were divided into group A(women with placental implantation)and group B(women without placental implantation)based on the results of placenta pathology after delivery as the gold standard.The serum levels of VEGF and sFlt-1 of women in the two groups were analyzed.And the effect of different methods of diagnosing placental implantation was also analyzed.Results:Serum VEGF level of women in group B(249.37±18.23 pg/ml)was significant lower than that(335.24±16.95 pg/ml)of women in group A,but the SFLT-1 level of women in group B(2939.93±28.99 pg/ml)was significant higher than that(2483.56±28.67 pg/ml)of women in group A.Serum VEGF and SFLT-1 levels of women during the third trimester of pregnancy were significant higher than those of women during the first and the second trimester of pregnancy,and those of women during the second trimester of pregnancy were significant higher than those of women during the first trimester of pregnancy.In group A,the serum VEGF and SFLT-1 levels of women with deep placental implantation were significant higher than those of women with shallow placental implantation(all P<0.05).The coincidence rate of the levels of serum VEGF and sFlt-1 combined with color ultrasound for diagnosing placental implantation was 88.6%,which had the highest diagnostic sensitivity(87.9%)and the lowest missed diagnosis rate(11.4%).Conclusion:The levels of serum VEGF and sFlt-1 combined with color ultrasound for diagnosing placental implantation of pregnant women has good clinical guiding significance.

关 键 词：胎盘植入 产前诊断 血管内皮生长因子 可溶性血管生长因子受体 多普勒超声 诊断价值 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.462[医药卫生—诊断学]