妊娠中晚期TORCH感染与出生缺陷发生关系分析  

Correlation between TORCH infection in women during the second and the third trimester of pregnancy and the occurrence of birth defects

作　　者：孙霞 董春忠[2] 陈玉香 马小玲 刘芳辉 SUN Xia;DONG Chunzhong;CHEN Yuxiang;MA Xiaoling;LIU Fanghui(Binzhou Maternal and Child Health Care Hospital,Binzhou,Shandong Province,256600;Binzhou People's Hospital)

机构地区：[1]山东省滨州市妇幼保健院,256600 [2]山东省滨州市人民医院

出　　处：《中国计划生育学杂志》2021年第1期149-151,155,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠中晚期TORCH感染与出生缺陷发生关系。方法:选择2015年2月-2019年1月本院产前检查孕妇3594例,取空腹外周静脉血行TORCH检测,根据筛查结果分为感染组254例与非感染组3340例。随访至分娩,记录出生缺陷发生情况。对比不同感染孕妇出生缺陷发生情况,分析与出生缺陷发生的相关性。结果:3594例中TORCH感染254例,感染率7.07%,CMV感染率(3.53%)最高,其次为TOX(1.53%),其他感染最低(P<0.05)。3954例新生儿有中49例伴有出生缺陷,其中单发畸形44例,多发畸形5例,总发生率为13.63‰。先天性心脏病发生率(5.56%)最高,其次为唇腭裂(3.90%),指/趾畸形(1.67%)、脊柱裂(1.39%),外耳畸形(1.11%)发生率较低(P<0.05)。感染组出生缺陷发生率(14.96%)高于非感染组(0.33%)(P<0.05)。先天性心脏病发生与CMV、TOX、RV及HSV感染呈显著正相关(r>0,P<0.05),与其他感染不具有相关性(P>0.05);唇腭裂发生与CMV感染呈显著正相关(r>0,P<0.05),与TOX、RV、HSV及其他感染不具有相关性(P>0.05)。指/趾畸形、脊柱裂及外耳畸形与TORCH感染不具有相关性(P>0.05)。结论:CMV、TOX、RV及HSV感染与先天性心脏病发生,CMV感染与腭裂发生有一定关系,提示临床应重视孕期TORCH检查,加强预防与治疗以降低出生缺陷发生。Objective:To explore the correlation between TORCH infection and the lower genital tract infection of women during the second and the third trimester of pregnancy and the occurrence of birth defects.Methods:3,594 pregnant women who had accepted TORCH examination were enrolled in this study from February 2015 to January 2019.According to the results of TORCH examination,these women were divided into group A(254 women with TORCH infection)and group B(3340 women without TORCH infection).All these women were followed up to delivery,and birth defects of their newborns were recorded.The rate of birth defects was compared between the two groups.The correlation between TORCH infection and birth defects was analyzed.Results:Among these 3594 pregnant women,there were 254(7.07%)cases with TORCH infection,which included the highest infection rate of CMV was 3.53%,and then followed by that(1.53%)of TOX infection,and the other infections were low.Among 3594 newborns,there were 49 cases with birth defects,which included 44 cases with single malformation and 5 cases with multiple malformations,and the total incidence of birth defects was 13.63‰.The incidence of congenital heart disease(5.56%)was the highest,then followed by cleft lip and palate(3.90%),finger/toe malformation(1.67%),spina bifida(1.39%),and external ear malformation(1.11%).The incidence of birth defects of newborns in group A(14.96%)was significant higher than that(0.33%)of newborns in group B(P<0.05).The incidence of congenital heart disease of newborns was positively associated with the infections of CMV,TOX,RV,and HSV of the pregnant women(r>0,P<0.05),but had no correlation with other infections(P>0.05).The incidence of cleft lip and palate was positively correlated with CMV infection(r>0,P<0.05),but had no correlation with the infections of TOX,RV and HSV,and other infections(P>0.05).The incidences of finger/toe deformity,spina bifida,and ear deformity were not correlated with TORCH infection(P>0.05).Conclusion:The infections of CMV,TOX,RV,and HSV of pregnan

关 键 词：妊娠中晚期 TORCH感染 出生缺陷 相关性 

分 类 号：R714.25[医药卫生—妇产科学]