高血压病人动态动脉硬化指数与血浆纤维蛋白原及D-二聚体的相关性研究  

Correlations of ambulatory arterial stiffness index with plasma fibrinogen and D-dimer in patients with hypertension

作　　者：朱雁洲[1] 刘晓斌[1] 郑原印[1] 范金茂 陈康 ZHU Yan-zhou;LIU Xiao-bin;ZHENG Yuan-yin;FAN Jin-mao;CHEN Kang(Department of Geriatrics,Mindong Hospital of Ningde Affiliated to Fujian Medical University,Fuan Fujian 355000,China)

机构地区：[1]福建医科大学附属宁德市闽东医院老年医学科,福建福安355000

出　　处：《蚌埠医学院学报》2020年第12期1658-1661,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨高血压病人动态动脉硬化指数(AASI)与血浆纤维蛋白原(FIB)及D-二聚体(D-D)的关系。方法:选取高血压病人220例,根据AASI中位数的大小分为A组(24 h AASI<0.52,n=106)和B组(24 h AASI≥0.52,n=114)。比较各组间血FIB、D-D水平,并进行Pearson/Spearman相关分析与多元线性回归分析。结果:A组的年龄、高血压病程、收缩压、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、FIB、D-D均低于B组(P<0.05)。Pearson或Spearman相关性分析显示,高血压病人AASI与年龄(r=0.231,P<0.05)、高血压病程(r=0.685,P<0.05)、收缩压(r=0.721,P<0.05)、血尿素氮(r=0.113,P<0.05)、总胆固醇(r=0.628,P<0.05)、LDL-C(r=0.666,P<0.05)、FIB(r=0.887,P<0.05)、D-D(r=0.668,P<0.05)相关。多元线性回归分析显示,AASI与病程(β=0.107,P<0.05)、收缩压(β=0.158,P<0.05)、LDL-C(β=0.102,P<0.05)、FIB(β=0.585,P<0.05)、D-D(β=0.139,P<0.05)相关。结论:高血压病人AASI与血浆FIB及D-D相关,临床上通过药物干预血FIB及D-D的值可能延缓或控制动脉粥样硬化的进程。Objective:To investigate the relationship between ambulatory arterial stiffness index(AASI)and plasma fibrinogen(FIB)and D-dimer(D-D)in patients with hypertension.Methods:According to the median value of AASI,220 patients with hypertension were divided into group A(24 h AASI<0.52,n=106)and group B(24 h AASI≥0.52,n=114).The levels of FIB and D-D were compared between the two groups.Pearson or Spearman correlation analysis and multiple linear regression analysis were performed.Results:The age,duration of hypertension,systolic blood pressure,total cholesterol,low density lipoprotein cholesterol(LDL-C),FIB and D-D in group A were lower than those in group B(P<0.05).Pearson or Spearman correlation analysis showed that AASI in patients with hypertension was correlated with age(r=0.231,P<0.05),duration of hypertension(r=0.685,P<0.05),systolic blood pressure(r=0.721,P<0.05),blood urea nitrogen(r=0.113,P<0.05),total cholesterol(r=0.628,P<0.05),LDL-C(r=0.666,P<0.05),FIB(r=0.887,P<0.05),and D-D(r=0.668,P<0.05).Multiple linear regression analysis showed that AASI was correlated with duration of disease(β=0.107,P<0.05),systolic blood pressure(β=0.158,P<0.05),LDL-C(β=0.102,P<0.05),FIB(β=0.585,P<0.05),and D-D(β=0.139,P<0.05).Conclusions:AASI in patients with hypertension is correlated with plasma FIB and D-D.Intervening the level of FIB and D-D by medicine may delay or control the progress of atherosclerosis.

关 键 词：高血压 动态动脉硬化指数 血纤维蛋白原 D-二聚体 

分 类 号：R544.1[医药卫生—心血管疾病]