mRNA和ncRNA在死亡时间推断中的研究进展  

Research Progress on Estimation of Postmortem Interval Using mRNA and ncRNA

作　　者：吕叶辉 王卓群 陈忆九 陈龙[3] LÜ Ye-hui;WANG Zhuo-qun;CHEN Yi-jiu;CHEN Long(School of Basic Medical Sciences,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China;Shanghai Key Laboratory of Forensic Medicine,Key Laboratory of Forensic Science,Ministry of Justice,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;Department of Forensic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China)

机构地区：[1]上海健康医学院基础医学院,上海201318 [2]司法鉴定科学研究院上海市法医学重点实验室司法部司法鉴定重点实验室上海市司法鉴定专业技术服务平台,上海200063 [3]复旦大学基础医学院法医学系,上海200032

出　　处：《法医学杂志》2020年第6期807-819,共13页Journal of Forensic Medicine

基　　金：上海市法医学重点实验室开放课题资助项目(KF1902);司法部司法鉴定重点实验室资助项目;上海市法医学重点实验室资助项目(17DZ2273200);上海市司法鉴定专业技术服务平台资助项目(19DZ2292700);国家自然科学基金面上项目(81671863,81373242,81172896)。

摘　　要：死亡时间(postmortem interval,PMI)推断一直是法医病理学研究的重点和难点。近年来,国内外学者运用死后体内核糖核酸(ribonucleic acid,RNA)特异性变化规律推断PMI取得了一定研究进展。本文结合文献,综述了运用信使RNA(messenger RNA,mRNA)和非编码RNA(non-coding RNA,ncRNA)进行PMI推断的具体应用方法,并探讨了存在的问题及发展趋势,以期为相关研究和鉴定实践提供技术参考。Postmortem interval(PMI)estimation has always been an important and difficult issue in the field of forensic pathology.In recent years,research progress on the estimation of PMI using RNA specific variation patterns after death has been made by researchers at home and aboard.This paper summarizes the specific application methods of messenger RNA and non-coding RNA for PMI estimation based on the literatures and discusses the existing problems and development trends,in order to provide technical reference for related studies and estimation practice.

关 键 词：法医病理学 死亡时间推断 信使RNA 非编码RNA 综述 

分 类 号：DF795.1[医药卫生—法医学]