阿替普酶与重组链激酶治疗急性ST段抬高型心肌梗死的效果和安全性对比分析  

Comparative analysis of the efficacy and safety of alteplase and recombinant streptokinase in the treatment of acute ST-segment elevation myocardial infarction

作　　者：李忠娟 高鹏 李冬梅 LI Zhongjuan;GAO Peng;LI Dongmei(Department of Emergency,the Second Affiliated Hospital of Mudanjiang Medical University,Heilongjiang,Mudanjiang 157000,China;Department of Emergency,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang,Mudanjiang 157000,China;Department of Physical Diagnosis,the Second Affiliated Hospital of Mudanjiang Medical University,Heilongjiang,Mudanjiang 157000,China)

机构地区：[1]牡丹江医学院附属第二医院急诊科,黑龙江牡丹江157000 [2]牡丹江医学院附属红旗医院急诊科,黑龙江牡丹江157000 [3]牡丹江医学院附属第二医院物理诊断科,黑龙江牡丹江157000

出　　处：《中国医药科学》2020年第24期102-104,共3页China Medicine And Pharmacy

摘　　要：目的对比分析阿替普酶与重组链激酶治疗急性ST段抬高型心肌梗死的效果和安全性。方法将我院接诊的60例急性ST段抬高型心肌梗死患者进行电脑随机分组,对照组30例,试验组30例,病例纳入时间为2018年6月~2020年6月,对应实施重组链激酶、阿替普酶治疗,分析效果及安全性。结果试验组血管再通率为93.33%高于对照组,差异有统计学意义(P<0.05)。试验组心源性休克、心力衰竭、恶性心律失常发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,试验组CK、GOT和CK-MB水平低于对照组,BNP、Hcy、cTnT低于对照组,差异有统计学意义(P<0.05)。结论与重组链激酶治疗急性ST段抬高型心肌梗死比较,阿替普酶效果更优,安全性更高。Objective To compare andanalyze the efficacy and safety of alteplase and recombinant streptokinase in the treatment of acute ST-segment elevation myocardial infarction.Methods A total of 60 patients with acute STsegment elevation myocardial infarction treated in our hospital were randomly divided into the control group(n=30)and the experimental group(n=30)by computer.Being included from June 2018 to June 2020,the cases were treated with recombinant streptokinase and alteplase respectively,and the efficacy and safety were analyzed.Results The recanalization rate of the experimental group was 93.33%,which was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidences of cardiogenic shock,heart failure and malignant arrhythmia in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CK,GOT and CK-MB in the experimental group were lower than those in the control group,meanwhile,BNP,Hcy and cTnT were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Compared with recombinant streptokinase in the treatment of acute ST-segment elevation myocardial infarction,alteplase is more effective and has higher safety.

关 键 词：阿替普酶 重组链激酶 急性ST段抬高型心肌梗死 安全性 

分 类 号：R542.2[医药卫生—心血管疾病]