N-取代-1,2,3-三氮唑化合物的合成研究进展  

Recent Progress in the Synthesis of N-Substituted-1,2,3-triazoles

作　　者：刘启顺 吕玉芬 鲍鹏丽 岳会兰[2] 魏伟[1,2] Liu Qishun;LüYufen;Bao Pengli;Yue Huilan;Wei Wei(School of Chemistry and Chemical Engineering,Qufu Normal University,Qufu,Shandong 273165;Key Laboratory of Tibetan Medicine Research,Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008)

机构地区：[1]曲阜师范大学化学与化工学院,山东曲阜273165 [2]中国科学院西北高原生物研究所,中国科学院藏药研究重点实验室,西宁810008

出　　处：《有机化学》2020年第12期4015-4030,共16页Chinese Journal of Organic Chemistry

基　　金：山东省高校青创科技计划(No.2019KJC021);国家自然科学基金(No.ZR2018MB009);青海省国际合作专项(No.2018-HZ-806)资助项目。

摘　　要：N-取代-1,2,3-三氮唑是一类重要的含氮杂环化合物,在药物化学、合成化学及材料等领域都具有广泛的应用价值.因此,N-取代-1,2,3-三氮唑的构建方法备受人们的关注.归纳总结了近年来N-取代-1,2,3-三氮唑的合成研究进展,主要介绍了以叠氮化合物、腙、TsNHNH2和重氮为氮源以及NH-1,2,3-三氮唑为前体合成N-取代-1,2,3-三氮唑化合物的合成路线及其反应机理,并对该领域未来的发展进行了展望.N-Substituted-1,2,3-triazoles are an important class of nitrogen-containing hetrocyclic compounds,which exhibited wide applications in various fields such as medicinal chemistry,synthetic chemistry and materials.Therefore,their synthetic methods have attracted great attention of chemists.Herein,the recent research progress in the synthesis of N-substituted-1,2,3-triazoles is summarized.The synthetic routes and reaction mechanisms from raw materials such as azide compounds,diazo compounds,TsNHNH2,hydrazones and NH-1,2,3-triazoles are introduced and reviewed,respectively.Finally,the future development of this field is also prospected.

关 键 词：N-取代-1 2 3-三氮唑 叠氮化合物 腙 TsNHNH2 重氮 NH-1 2 3-三氮唑 

分 类 号：O626[理学—有机化学]