抗结核分枝杆菌生物碱Pseudopteroxazole和Ileabethoxazole的全合成研究进展  

Synthetic Progress of Alkaloids against Mycobacterium Tuberculosis:Pseudopteroxazole and Ileabethoxazole

作　　者：孙泽众 徐苗 王云侠[1] 胡向东[1] Sun Zezhong;Xu Miao;Wang Yunxia;Hu Xiangdong(Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,College of Chemistry&Materials Science,Northwest University,Xi’an 710127)

机构地区：[1]西北大学化学与材料科学学院合成与天然功能分子教育部重点实验室,西安710127

出　　处：《有机化学》2020年第12期4203-4215,共13页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21772153);陕西省科技厅基金(No.S2019-JC-YB-0846);陕西省重点科技创新团队基金(No.2017KCT-37)资助项目。

摘　　要：从海鞭Pseudopterogorgiaelisabethae中分离得到的生物碱pseudopteroxazole和ileabethoxazole对结核病病原体——结核分枝杆菌具有良好的抗菌活性.这两种生物碱具有相似的四环骨架,包含四个立体中心、一个全取代苯环和天然产物中少有的苯并恶唑单元.良好的抗结核分枝杆菌活性和独特的分子结构使得对pseudopteroxazole和ileabethoxazole的合成研究得到了广泛关注,综述了国内外对这两生物碱的全合成研究进展.Two alkaloids of pseudopteroxazole and ileabethoxazole,isolated from sea whip Pseudopterogorgia elisabethae,have significant antimicrobial activity against pathogen of tuberculosis:Mycobacterium tuberculosis.These two alkaloids possess similar tetracyclic skeleton,which containing four stereocenters,a fully substituted aromatic ring and an uncommon benzoxazole unit in natural products.Significant antimicrobial activity and special molecular structures attracted extensive attentions to synthetic study on pseudopteroxazole and ileabethoxazole.The progress in the total synthesis of these two alkaloids is reviewed.

关 键 词：结核分枝杆菌 生物碱 pseudopteroxazole ileabethoxazole 全合成 

分 类 号：TQ464[化学工程—制药化工] O629.3[理学—有机化学]