含异噁唑环的新型N-吡啶基吡唑酰胺化合物的合成及生物活性研究  

Synthesis and Biological Activities of Novel N-Pyridylpyrazole Amide Compounds Carrying Isoxazole Unit

作　　者：郑丹丹 倪亚丹 钱程 张敏 张紫婵 戴红[1] 周贝贝 张莉芳 Zheng Dandan;Ni Yadan;Qian Cheng;Zhang Min;Zhang Zichan;Dai Hong;Zhou Beibei;Zhang Lifang(College of Chemistry and Chemical Engineering,Nantong University,Nantong,Jiangsu 226019)

机构地区：[1]南通大学化学化工学院,江苏南通226019

出　　处：《有机化学》2020年第12期4249-4257,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21372135);南通市科技计划(No.MS12019060)资助项目。

摘　　要：基于新型杀虫剂氯虫苯甲酰胺的结构,设计合成出一系列新型含取代异噁唑单元的N-吡啶基吡唑酰胺衍生物,其目标化合物的结构均经核磁氢谱、碳谱及元素分析等方法确证.初步的室内杀虫活性测试数据表明,在500μg/mL测试浓度下,所有目标化合物对粘虫的杀虫效果均达100%.4个化合物在100μg/m L测试浓度下对粘虫的杀死率为80%~100%,2个化合物在20μg/m L测试浓度下对粘虫仍有40%~50%的防效.5个化合物在500μg/m L测试浓度下对蚜虫有较高的杀虫作用,其致死率为90%~100%.此外,2个化合物在500μg/m L测试浓度下对朱砂叶螨有70%~80%的致死率.A series of new N-pyridylpyrazole amides bearing substituted isoxazole moiety were designed and prepared based on chlorantraniliprole.These compounds were structurally determined through 1 H NMR,13 C NMR and elemental analyses.Bioassay results displayed that all designed compounds showed a mortality rate of 100%towards Oriental armyworm at the dosage of 500μg/m L.At the dosage of 100μg/m L,the mortality rates of four compounds towards Oriental armyworm were 80%~100%.Two compounds had 40%~50%insecticidal activities towards Oriental armyworm at the concentration of 20μg/mL.At the concentration of 500μg/mL,five compounds demonstrated 90%~100%insecticidal activities against Aphis medicaginis.Moreover,at the dosage of 500μg/mL,two compounds exhibited 70%~80%insecticidal activities against Tetranychus cinnabarinus.

关 键 词：异噁唑 N-吡啶基吡唑 合成 生物活性 

分 类 号：TQ453.2[化学工程—农药化工]