无溶剂无催化剂条件下三组分一锅合成2,4,6-三芳基嘧啶衍生物的新方法  

Novel Three-Component Annulation for the Synthesis of 2,4,6-Triarylpyrimidines under Solvent-Free and Catalyst-Free Conditions

作　　者：丁雨昕 马永敏[1,2] 陈静 Ding Yuxin;Ma Yongmin;Chen Jing(School of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou、Zhejiang 310053;School of Pharmaceutical and Chemical Engineering,Taizhou University,Taizhou,Zhejiang 318000)

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]台州大学医药化工学院,浙江台州318000

出　　处：《有机化学》2020年第12期4357-4363,共7页Chinese Journal of Organic Chemistry

基　　金：浙江省自然科学基金(No.LY19H300001);浙江中医药大学校级科研基金(No.2018ZG31);2019年度高等学校国内访问者“教师专业发展项目”(No.FX2019020)资助项目。

摘　　要：以1,3-二酮、苯甲醛和醋酸铵为原料,成功地开发了一种简便、高效、无溶剂和催化剂的三组分一锅合成法,高收率地得到了2,4,6-三芳基嘧啶化合物.此方法提供了一条"绿色"合成嘧啶骨架新策略.2,4,6-Triarylpyrimidines were synthesized via a simple,efficient,one-pot,three-component reaction from1,3-dikeones,benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields.This"green"methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.

关 键 词：无催化剂 无溶剂 一锅法 三组分反应 2 4 6-三芳基嘧啶 

分 类 号：O626.41[理学—有机化学]