胎儿真皮间充质干细胞在烧伤创面治疗中的作用研究进展  

Research advances on the application of fetal dermal mesenchymal stem cells in burn wound treatment

作　　者：潘伊 姜笃银[2] Pan Yi;Jiang Duyin(Department of Rehabilitation Medicine,the Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250033,China;Department of Emergency,the Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250033,China)

机构地区：[1]山东大学第二医院康复医学科,济南250033 [2]山东大学第二医院急诊医学中心,济南250033

出　　处：《中华烧伤杂志》2021年第1期86-89,共4页Chinese Journal of Burns

基　　金：国家自然科学基金(81873934);济南市科技攻关项目(201704129)。

摘　　要：胎儿真皮间充质干细胞(FDMSC)是从不携带遗传疾病且未应用流产药物的健康孕妇意外流产胎儿皮肤中提取的一种多功能干细胞,具有外泌体分泌活性,增殖和自我更新能力强,免疫原性低,可向损伤组织归巢,促进组织再生等优点。近年来对FDMSC基本生物学特性、体外诱导分化能力、促进皮肤创面修复等的研究,为未来烧伤患者的临床治疗提供了新方向。本文就FDMSC促进烧伤创面愈合的研究进展进行综述。Fetal dermal mesenchymal stem cells(FDMSCs)are pluripotent stem cells derived from skin tissue of accidentally aborted fetuses of healthy pregnant women who are free of genetic diseases and do not take abortion drug.FDMSCs have exosome secretion activity,high proliferation and self-renewal abilities,low immunogenicity,and advantages of homing to damaged tissue and promoting tissue regeneration.In recent years,studies on basic biological characteristics,capacity of inducing differentiation in vitro,and promotion of skin wound repair provide new direction for the clinical treatment of burn patients in the future.In this review,we summarize the research advances of FDMSCs in promoting burn wound healing.

关 键 词：烧伤 伤口愈合 胎儿真皮间充质干细胞 

分 类 号：R632.1[医药卫生—外科学] R96[医药卫生—临床医学]