Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors:a cost-effective supplement for malaria interventions  

作　　者：Guofa Zhou Eugenia Lo Andrew K.Githeko Yaw A.Afrane Guiyun Yan 

机构地区：[1]Program in Public Health,University of California,Irvine,CA,92697,USA [2]Department of Biological Sciences,University of North Carolina,Charlotte,NC,28223,USA [3]Central for Global Health Research,Kenya Medical Research Institute,Kisumu,Kenya [4]Department of Medical Microbiology,University of Ghana,Accra,Ghana

出　　处：《Infectious Diseases of Poverty》2020年第6期83-90,共8页贫困所致传染病（英文）

基　　金：This work was supported by the National Institutes of Health(R01 A1050243,U19 AI129326 and D43 TW001505).

摘　　要：The issues of pyrethroid resistance and outdoor malaria parasite transmission have prompted the WHO to call for the development and adoption of viable alternative vector control methods.Larval source management is one of the core malaria vector interventions recommended by the Ministry of Health in many African countries,but it is rarely implemented due to concerns on its cost-effectiveness.New long-lasting microbial larvicide can be a promising cost-effective supplement to current vector control and elimination methods because microbial larvicide uses killing mechanisms different from pyrethroids and other chemical insecticides.It has been shown to be effective in reducing the overall vector abundance and thus both indoor and outdoor transmission.In our opinion,the long-lasting formulation can potentially reduce the cost of larvicide field application,and should be evaluated for its cost-effectiveness,resistance development,and impact on non-target organisms when integrating with other malaria vector control measures.In this opinion,we highlight that long-lasting microbial larvicide can be a potential cost-effective product that complements current front-line long-lasting insecticidal nets(LLINs)and indoor residual spraying(IRS)programs for malaria control and elimination.Microbial larviciding targets immature mosquitoes,reduces both indoor and outdoor transmission and is not affected by vector resistance to synthetic insecticides.This control method is a shift from the conventional LLINs and IRS programs that mainly target indoor-biting and resting adult mosquitoes.

关 键 词：Long-lasting microbial larvicide COST-EFFECTIVENESS Supplemental tool Malaria control and elimination 

分 类 号：R184.31[医药卫生—流行病学]