Imported Mansonella perstans infection in Spain  

作　　者：Sabino Puente Mar Lago Mercedes Subirats Ismael Sanz-Esteban Marta Arsuaga Belén Vicente Montserrat Alonso-Sardon Moncef Belhassen-Garcia Antonio Muro 

机构地区：[1]Unidad de Medicina Tropical,Servicio de Medicina Interna,Hospital La Paz-Carlos III,Madrid,Spain [2]Microbiología,Hospital La Paz-Carlos III,Madrid,Spain [3]Facultad de Fisioterapia,Universidad Europea de Madrid,Madrid,Spain [4]Laboratorio de Inmunología Parasitaria y Molecular,CIETUS,IBSAL,Facultad de Farmacia,Universidad de Salamanca,37007,Salamanca,Spain [5]Área de Medicina Preventiva y Salud Pública,IBSAL,CIETUS,Universidad de Salamanca,Salamanca,Spain [6]Servicio de Medicina Interna,Sección de Enfermedades Infecciosas,CAUSA,IBSAL,CIETUS,Universidad de Salamanca,Paseo San Vicente 58-182,37007,Salamanca,Spain

出　　处：《Infectious Diseases of Poverty》2020年第4期158-158,共1页贫困所致传染病（英文）

摘　　要：Background Mansonella perstans infection can be considered one of the most neglected tropical infectious diseases.Very few studies have reported on the clinical picture caused by infection with this nematode.Therefore,our study was aimed to describe the clinical patterns and treatment of imported M.perstans infection by migrants from Africa.Methods The present study evaluated a large cohort of migrants who have been diagnosed,examined and treated for imported M.perstans infection at a Spanish reference center(Hospital Carlos III Tropical Medicine Unit,Madrid,Spain)over a 19-year period.Most patients voluntarily attend the emergency unit or are referred from primary care or general hospitals in Madrid.Chi-square test was used to compare the association between categorical variables.The continuous variables were compared by Student’s t-test or the Mann–Whitney test.The corresponding regression models were used for multivariate analysis.Results Five hundred three cases of migrants from tropical and subtropical areas with M.perstans infection were identified.Two hundred sixty-four patients were female(52.5%).The mean age(±SD)was 44.6±18.2 years(range:16–93 years).The mean time(±SD)between the arrival in Spain and the first consultation was 8.6±18.0 months.The major origin of the patients was Equatorial Guinea(97.6%).Regarding the clinical picture,257 patients were asymptomatic(54.7%)and 228 were symptomatic(45.3%);190 patients had pruritus(37.8%),50(9.9%)had arthralgia,18 patients had Calabar-like swelling(3.6%),and 15(3%)had abdominal pain.Four hundred forty-two(87.9%)migrants had hyper-IgE,and 340(67.6%)had eosinophilia.One hundred ninety-five patients had coinfections with other filarial nematodes(38.8%),and 308 migrants had only M.perstans infection(61.2%).Four hundred thirty-seven cases(86.9%)had been treated with anti-filarial drugs;292 cases were treated with one anti-filarial drug,and 145 cases were treated with combined anti-filarial therapy.Additionally,20(4%)cases received steroids and 38(7.6%)ca

关 键 词：Mansonellosis Mansonella perstans Clinical study IMMIGRANT Imported diseases Spain 

分 类 号：R531.9[医药卫生—内科学]