Cardiovascular characteristics of premature infants with Klebsiella Pneumoniae septicemia and shock  

作　　者：CHEN Lin HE Shao-ru LIU Yu-mei SUN Yun-xia ZHENG Man-li SUN Xin DONG Hui-ru 陈琳;何少茹;刘玉梅;孙云霞;郑曼利;孙新;董慧茹(Department of Neonatology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences)

机构地区：[1]Department of Neonatology,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong,China

出　　处：《South China Journal of Cardiology》2020年第4期256-262,共7页岭南心血管病杂志（英文版）

基　　金：supported by National key Program(No.2018 YFC1002600);Guangdong Medical Research Foundation(No.A2016177)。

摘　　要：Background The cardiovascular characteristics during septic shock in premature neonates are characterized by elevated ventricular output and normal ejection fraction.However,there is little knowledge about other variables in premature infants with Klebsiella Pneumoniae(KPN)septicemia and shock.This study aimed to investigate the characteristics of cardiovascular changes in premature infants diagnosed with Klebsiella pneumonia(KPN)septicemia and shock.Methods Our study included premature infants(gestational age≤34 weeks)in the neonatal intensive care unit(NICU)of Guangdong Provincial People.s Hospital from November 1 st,2013 to November 31 st,2016.17 participants diagnosed with KPN septicemia complicated with shock and 17 healthy premature infants were respectively enrolled in study group and control group for analysis.All the infants underwent non-invasive ultrasound cardiac output monitor examinations in normal time,early stage of shock and cured time.Results Compared with the control group,higher values of heart rate(HR)(P<0.001),cardiac output index(CI)(P<0.001),Smith-Madigan inotropy index(SMII)(P<0.001)and oxygen delivery(DO2)(P<0.001),and lower levels of systemic vascular resistance index(SVRI)(P<0.001)were observed in the study group.The difference of mean blood pressure(MBP)was not statistically significant(P=0.943).In the study group,the values of HR(P=0.004),CI(P=0.004),SMII(P=0.004)and DO2(P=0.004)in the early stage of septic shock were significantly higher when compared with the values in the normal time,while the value of SVRI(P<0.001)was significantly lower.HR(P<0.001)and DO2(P=0.009)decreased from the early stage of septic shock to the cured time,while SVRI(P<0.001)increased.There were no significant changes in CI(P>0.999)and SMII(P=0.646)from early stage of septic shock to improvement in the study group.Conclusions Systemic vascular resistance index decreased and oxygen deliver elevated in preterm infants with gestational age less than 34 weeks with Klebsiella Pneumoniae septicemia and shock.Vas

关 键 词：premature infant Klebsiella pneumonia septicemia shock cardiovascular change 

分 类 号：R722.6[医药卫生—儿科]